Buzás G M, Székely E
Ferencvárosi Egészségügyi Szolgálat, Budapest.
Orv Hetil. 1999 Jan 17;140(3):121-4.
The aim of this study was to compare in an open trial the efficacy of 2 x 500 mg clarithromycin + 2 x 1000 mg amoxicillin + 40 mg pantoprazole/day given for 7 days (I. group, 48 cases), with that of 2 x 500 mg clarithromycin + 2 x 400 mg ranitidine bismuth citrate/day given for 14 days (II. group, 51 cases). The diagnosis of peptic ulcer was established endoscopically. HP infection was confirmed the modified Giemsa stain and rapid urease test. After eradication all patients were given 2 x 150 mg ranitidine for one month. Controls were performed 4-6 weeks after eradication. Peptic ulcer healing was proven in the group I in 93.0% and in the group II in 91.6% (p > 0.05). On intention-to-treat basis, HP was eradicated in 80.3% (confidence interval, CI: 73-92.7%) in the I. and 80.3% (confidence interval: 76-95%) in the II. group (p > 0.05). Per protocol analysis revealed eradication rates of 88.3% (CI: 81-97.6%) and 85.4% (CI: 80-97%) (p > 0.05). Side effects were recorded in 9.5% and 14.5% of the cases. Both regimens were equally effective in the eradication of HP and healing of peptic ulcers.
每天给予2×500毫克克拉霉素 + 2×1000毫克阿莫西林 + 40毫克泮托拉唑，疗程7天（I组，48例）；以及每天给予2×500毫克克拉霉素 + 2×400毫克枸橼酸铋雷尼替丁，疗程14天（II组，51例）。消化性溃疡的诊断通过内镜检查确定。幽门螺杆菌（HP）感染通过改良吉姆萨染色和快速尿素酶试验确诊。根除治疗后，所有患者均给予2×150毫克雷尼替丁，持续1个月。在根除治疗后4 - 6周进行复查。I组消化性溃疡愈合率为93.0%，II组为91.6%（p>0.05）。在意向性分析中，I组HP根除率为80.3%（置信区间，CI：73 - 92.7%），II组为80.3%（置信区间：76 - 95%）（p>0.05）。符合方案分析显示根除率分别为88.3%（CI：81 - 97.6%）和85.4%（CI：80 - 97%）（p>0.05）。记录到的副作用发生率分别为9.5%和14.5%。两种治疗方案在根除HP和治愈消化性溃疡方面同样有效。
