[布鲁氏菌病保护性抗原对细胞吞噬活性的影响]
[Effect of brucellosis protective antigen on the phagocytic activity of the cells].
作者信息
Chernysheva M I, Dranovskaia E A
出版信息
Zh Mikrobiol Epidemiol Immunobiol. 1978 Apr(4):80-4.
The authors present the results of study of the protective function of cells of the local inflammatory focus caused by the administration of live brucella culture to guinea pigs immunized with a protective antigen in the optimal (0.6) and increased (2 mg) doses. Macrophages of guinea pigs vaccinated with the optimal immunized dose of the protective antigen phagocytized brucellae actively; an increased dose of the antigen suppressed the ingestive and the digestive functions of macrophages, this apparently being caused by the manifestation of the immunodepressive activity of the residual amount of lipopolysaccharide (endotoxin) in the protective antigen.
作者介绍了给用最佳剂量（0.6毫克）和增加剂量（2毫克）的保护性抗原免疫的豚鼠接种活布鲁氏菌培养物后，局部炎症灶细胞保护功能的研究结果。用最佳免疫剂量的保护性抗原接种的豚鼠巨噬细胞能积极吞噬布鲁氏菌；抗原剂量增加会抑制巨噬细胞的摄取和消化功能，这显然是由保护性抗原中残留的脂多糖（内毒素）免疫抑制活性的表现所导致的。
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