Aronski A, Kübler A, Majda A, Jakubaszko J
Anaesth Resusc Intensive Ther. 1975 Jul-Sep;3(3):221-30.
The comparative study of 2 narcotic antagonists, naloxone and nalorphine, was performed in healthy volunteers. The influence of these drugs on the respiratory and cicularoty systems and on the psychical state was compared. The study was carried out in a double-blind, cross-over manner. Increasing doses of naloxone and placebo or nalorphine and placebo, were administered intravenously. Naloxone, even in very high doses, caused no changes in cardivascular system, acid-base balance, sensitivity of respiratory centre to carbon dioxide and psychical state of volunteers. After the administration of nalorphine, even in very small doses, changes in psychical state in all examined subjects were observed. Nalorphine caused the significant change in the ventilatory response to CO2. Based on their results, the authors conclude that naloxone has no agonist or intrinsic narcotic activity, as opposed to nalorphine possessing strong narcotic action.
在健康志愿者中对两种麻醉拮抗剂纳洛酮和烯丙吗啡进行了对比研究。比较了这些药物对呼吸和循环系统以及精神状态的影响。该研究采用双盲、交叉方式进行。静脉注射递增剂量的纳洛酮与安慰剂或烯丙吗啡与安慰剂。即使是非常高的剂量，纳洛酮也不会引起志愿者心血管系统、酸碱平衡、呼吸中枢对二氧化碳的敏感性及精神状态的变化。注射烯丙吗啡后，即使是非常小的剂量，也观察到所有受试对象的精神状态发生了变化。烯丙吗啡引起了对二氧化碳通气反应的显著变化。基于这些结果，作者得出结论，与具有强烈麻醉作用的烯丙吗啡相反，纳洛酮没有激动剂或内在麻醉活性。
