Savege T M, Colvin M P, Weaver E J, Bond C, Drake J, Inniss R
Br J Anaesth. 1976 Nov;48(11):1071-81. doi: 10.1093/bja/48.11.1071.
Cardiorespiratory effects of ketamine and Althesin were measured in two groups of premedicated patients with cardiac disease. The drugs were given in clinically equivalent doses with a second dose administered about 10 min after induction. The first dose of ketamine caused a marked increase in systemic and pulmonary arterial pressure, heart rate, and central venous and wedge pressures and cardiac index. The first dose of Althesin caused a decrease in systemic arterial pressure, central venous pressure, cardiac index and heart work, but little change in heart rate. The second dose of induction agent was administered before the cardiorespiratory effects of the initial dose had resolved. The second dose of Althesin caused changes similar to those following the first dose, but less marked. The changes following the second dose of ketamine were opposite to those following the first dose.
在两组患有心脏病且已进行术前用药的患者中，对氯胺酮和安泰酮的心肺效应进行了测量。以临床等效剂量给药，诱导后约10分钟给予第二剂。氯胺酮的第一剂导致全身和肺动脉压、心率、中心静脉压和楔压以及心脏指数显著升高。安泰酮的第一剂导致全身动脉压、中心静脉压、心脏指数和心脏作功降低，但心率变化不大。在初始剂量的心肺效应消退之前给予第二剂诱导剂。安泰酮的第二剂引起的变化与第一剂后的变化相似，但不太明显。氯胺酮第二剂后的变化与第一剂后的变化相反。
