[Experimental terato-carcinoma: behavior of embryoid bodies inoculated into the abdominal cavity of syngeneic mice].

A suspension of CE "44" embryoïd-bodies obtained from a transplanted OTT 60-50 subline was injected into the abdominal cavity of syngeneic L 129 mice. Terato-carcinoma and ascitic fluid were produced the latter containing embryoïds. In situ examinations were made by serial transverse sectioning of the entire abdomen. The reconstruction of the sequence of events occuring after inoculation was achieved by killing the animals at different time after inoculation. This analysis showed that embryoïd-bodies appear quite similar to blastulas and that they are attracted to evolving granulomas in the peritoneum. Blastulas attach through their outer wall which then breaks to permit the inner-cell masses to penetrate through the hole and contribute towards the subsequent development of terato-carcinomas.