Steward M W, Petty R E
Immunology. 1976 Jun;30(6):789-97.
The amount (Abt) and relative affinity (KR) of antibody produced in response to protein antigens injected in saline has been measured in the parents, F1 hybrids and backcross offspring of inbred mice which produce high and low KR antibody to these antigens. The results obtained support the view that antibody affinity is under polygenic control. Furthermore, strain related variation in Abt is independent of KR and the breeding experiments indicate that these two parameters are under independent genetic control.
已对在生理盐水中注射蛋白质抗原后产生的抗体量(Abt)和相对亲和力(KR)进行了测定,这些抗原是注射到近交系小鼠的亲本、F1杂种和回交后代体内的,这些近交系小鼠针对这些抗原产生高KR和低KR抗体。所获得的结果支持了抗体亲和力受多基因控制的观点。此外,Abt中与品系相关的变异独立于KR,育种实验表明这两个参数受独立的遗传控制。