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Degradation of hepatic haem to porphyrins and oxophlorins in rats treated with 2-allyl-2-isopropylacetamide.

作者信息

McDonagh A F, Pospisil R, Meyer U A

出版信息

Biochem Soc Trans. 1976;4(2):297-8. doi: 10.1042/bst0040297.

DOI:10.1042/bst0040297
PMID:1001669
Abstract
摘要

相似文献

1
Degradation of hepatic haem to porphyrins and oxophlorins in rats treated with 2-allyl-2-isopropylacetamide.用2-烯丙基-2-异丙基乙酰胺处理的大鼠肝脏血红素降解为卟啉和氧化卟啉。
Biochem Soc Trans. 1976;4(2):297-8. doi: 10.1042/bst0040297.
2
Metabolism of hepatic haem and 'green pigments' in rats given 2-allyl-2-isopropylacetamide and ferric citrate. A new model for hepatic haem turnover.给予2-烯丙基-2-异丙基乙酰胺和柠檬酸铁的大鼠肝脏血红素和“绿色色素”的代谢。肝脏血红素周转的新模型。
Biochem J. 1980 May 15;188(2):289-95. doi: 10.1042/bj1880289.
3
Increased liver haem degradation caused by foreign chemicals: a comparison of the effects of 2-allyl-2-isopropylacetamide and cobaltous chloride.外来化学物质引起的肝脏血红素降解增加:2-烯丙基-2-异丙基乙酰胺与氯化钴的作用比较
Biochem Soc Trans. 1976;4(2):205-9. doi: 10.1042/bst0040205.
4
Substrate-dependent irreversible inactivation of cytochrome P-450: conversion of its haem moiety into modified porphyrins.细胞色素P-450的底物依赖性不可逆失活:其血红素部分转化为修饰的卟啉。
Ciba Found Symp. 1980;76:119-39. doi: 10.1002/9780470720592.ch8.
5
Degradation of cytochrome P-450 haem by carbon tetrachloride and 2-allyl-2-isopropylacetamide in rat liver in vivo and in vitro. Involvement of non-carbon monoxide-forming mechanisms.四氯化碳和2-烯丙基-2-异丙基乙酰胺在大鼠肝脏体内外对细胞色素P-450血红素的降解作用。非一氧化碳生成机制的参与。
Biochem J. 1979 Dec 15;184(3):481-9. doi: 10.1042/bj1840481.
6
Effect of desferrioxamine and chronic iron deficiency of heme metabolism--comparison with the porphyrogens 2-allyl-2-isopropylacetamide and 3,5-diethoxycarbonyl-1,4-dihydrocollidine.去铁胺和慢性铁缺乏对血红素代谢的影响——与致卟啉原2-烯丙基-2-异丙基乙酰胺和3,5-二乙氧基羰基-1,4-二氢可力丁的比较。
Biochem Pharmacol. 1979 Jun 1;28(11):1753-8. doi: 10.1016/0006-2952(79)90536-7.
7
Formation of cytochrome P-450 containing haem or cobalt-protoporphyrin in liver homogenates of rats treated with phenobarbital and allylisopropylacetamide.用苯巴比妥和烯丙异丙基乙酰胺处理的大鼠肝脏匀浆中含血红素或钴原卟啉的细胞色素P - 450的形成。
Biochem J. 1984 Sep 1;222(2):453-62. doi: 10.1042/bj2220453.
8
Evidence for the catalytic activity of endogenous iron in the lipid peroxidative destruction of heme by allylisopropylacetamide in the rat liver.大鼠肝脏中内源性铁在烯丙基异丙基乙酰胺对血红素脂质过氧化破坏过程中的催化活性证据。
Int J Biochem. 1980;12(5-6):781-5. doi: 10.1016/0020-711x(80)90162-7.
9
Tryptophan pyrrolase in haem regulation. The relationship between the depletion of rat liver tryptophan pyrrolase haem and the enhancement of 5-aminolaevulinate synthase activity by 2-allyl-2-isopropylacetamide.色氨酸吡咯酶在血红素调节中的作用。大鼠肝脏色氨酸吡咯酶血红素的消耗与2-烯丙基-2-异丙基乙酰胺对5-氨基酮戊酸合酶活性增强之间的关系。
Biochem J. 1980 Mar 15;186(3):763-72. doi: 10.1042/bj1860763.
10
Destruction of endogenous and exogenous haem by 2-allyl-2-isopropylacetamide: role of the liver cytochrome P-450 which is inducible by phenobarbitone.2-烯丙基-2-异丙基乙酰胺对内源性和外源性血红素的破坏作用:苯巴比妥可诱导的肝脏细胞色素P-450的作用。
Int J Biochem. 1978;9(12):865-9. doi: 10.1016/0020-711x(78)90061-7.

引用本文的文献

1
Inhibition of protohaem ferro-lyase in experimental porphyria. Isolation and partial characterization of a modified porphyrin inhibitor.实验性卟啉症中原卟啉铁裂解酶的抑制作用。一种修饰卟啉抑制剂的分离及部分特性鉴定。
Biochem J. 1980 Apr 15;188(1):145-52. doi: 10.1042/bj1880145.
2
Loss of haem from cytochrome P-450 caused by lipid peroxidation and 2-allyl-2-isoprophylacetamide. An abnormal pathway not involving production of carbon monoxide.脂质过氧化和2-烯丙基-2-异丙基乙酰胺导致细胞色素P-450中血红素的丧失。这是一条不涉及一氧化碳产生的异常途径。
Biochem J. 1977 Dec 15;168(3):417-22. doi: 10.1042/bj1680417.
3
Alteration of the porphyrin nucleus of cytochrome P-450 caused in the liver by treatment with allyl-containing drugs. Is the modified porphyrin N-substituted?
含烯丙基药物处理导致肝脏中细胞色素P - 450的卟啉核发生改变。修饰后的卟啉是N - 取代的吗?
Biochem J. 1979 Oct 1;183(1):99-103. doi: 10.1042/bj1830099.
4
Studies on the mechanism of experimental porphyria produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Role of a porphyrin-like inhibitor of protohaem ferro-lyase.3,5 - 二乙氧羰基 - 1,4 - 二氢可力丁所致实验性卟啉症机制的研究。一种原卟啉亚铁裂解酶的卟啉样抑制剂的作用。
Biochem J. 1979 Apr 15;180(1):241-4. doi: 10.1042/bj1800241.
5
Self-catalyzed destruction of cytochrome P-450: covalent binding of ethynyl sterols to prosthetic heme.
Proc Natl Acad Sci U S A. 1979 Feb;76(2):746-9. doi: 10.1073/pnas.76.2.746.