含烯丙基药物处理导致肝脏中细胞色素P - 450的卟啉核发生改变。修饰后的卟啉是N - 取代的吗？
Alteration of the porphyrin nucleus of cytochrome P-450 caused in the liver by treatment with allyl-containing drugs. Is the modified porphyrin N-substituted?
作者信息
De Matteis F, Cantoni L
出版信息
Biochem J. 1979 Oct 1;183(1):99-103. doi: 10.1042/bj1830099.
Abstract
A spectral study was carried out of the green pigments produced by allyl-containing drugs and a comparison made with N-methylated octaethylporphyrin and 2,4-diformyldeuteroporphyrin. The green pigments resemble the former (and markedly differ from the latter) in the intensity of the bathochromic shifts, titration curves with trifluoroacetic acid and rate of incorporation of metal ions in vitro.
摘要
对含烯丙基药物产生的绿色色素进行了光谱研究，并与N-甲基化八乙基卟啉和2,4-二甲酰基原卟啉进行了比较。这些绿色色素在红移强度、与三氟乙酸的滴定曲线以及体外金属离子掺入速率方面与前者相似（与后者明显不同）。
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Alteration of the porphyrin nucleus of cytochrome P-450 caused in the liver by treatment with allyl-containing drugs. Is the modified porphyrin N-substituted?含烯丙基药物处理导致肝脏中细胞色素P - 450的卟啉核发生改变。修饰后的卟啉是N - 取代的吗？
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本文引用的文献
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Porphyrins with formyl groups. III. Preparation of chlorocruoroporphyrin and diformyldeuteroporphyrin.带有甲酰基的卟啉。III. 氯高铁血红素卟啉和二甲酰基氘卟啉的制备。
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Rapid loss of cytochrome P-450 and haem caused in the liver microsomes by the porphyrogenic agent 2-allyl-2-isopropylacetamide.致卟啉剂2-烯丙基-2-异丙基乙酰胺导致肝脏微粒体中细胞色素P-450和血红素迅速丧失。
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Formylation of iron (3) porphyrins and chlorins of natural origin.天然来源的铁（III）卟啉和二氢卟酚的甲酰化反应。
J Chem Soc Perkin 1. 1970;7:903-10. doi: 10.1039/j39700000903.
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Loss of haem in rat liver caused by the porphyrogenic agent 2-allyl-2-isopropylacetamide.由致卟啉剂2-烯丙基-2-异丙基乙酰胺引起的大鼠肝脏血红素损失。
Biochem J. 1971 Oct;124(4):767-77. doi: 10.1042/bj1240767.
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N-methylporphyrins.N-甲基卟啉
Ann N Y Acad Sci. 1973;206:151-76. doi: 10.1111/j.1749-6632.1973.tb43210.x.
6
Breakdown of cytochrome P-450 heme by secobarbital and other allyl-containing barbiturates.司可巴比妥及其他含烯丙基巴比妥类药物对细胞色素P-450血红素的分解作用。
Drug Metab Dispos. 1973 Jan-Feb;1(1):275-85.
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Drug-induced destruction of cytochrome P-450.药物诱导的细胞色素P-450破坏。
Drug Metab Dispos. 1973 Jan-Feb;1(1):267-74.
8
Degradation of hepatic haem to porphyrins and oxophlorins in rats treated with 2-allyl-2-isopropylacetamide.用2-烯丙基-2-异丙基乙酰胺处理的大鼠肝脏血红素降解为卟啉和氧化卟啉。
Biochem Soc Trans. 1976;4(2):297-8. doi: 10.1042/bst0040297.
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Increased liver haem degradation caused by foreign chemicals: a comparison of the effects of 2-allyl-2-isopropylacetamide and cobaltous chloride.外来化学物质引起的肝脏血红素降解增加：2-烯丙基-2-异丙基乙酰胺与氯化钴的作用比较
Biochem Soc Trans. 1976;4(2):205-9. doi: 10.1042/bst0040205.
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Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct.
Biochem Biophys Res Commun. 1978 Jul 14;83(1):132-7. doi: 10.1016/0006-291x(78)90407-2.
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