[不同类型辐射对雄性小鼠生殖细胞的诱变作用。X. 经分次γ射线照射的小鼠精原细胞中隐性致死突变和相互易位的频率]
[Mutagenic effect of different types of irradiation on the sex cells of male mice. X. Frequency of recessive lethal mutations and reciprocal translocations in the spermatogonia of mice subjected to fractional gamma-irradiation].
作者信息
Pomerantseva M D, Ramaĭia L K, Vilkina G A
出版信息
Genetika. 1976;12(7):56-63.
The frequency of recessive lethal mutations and reciprocal translocations was investigated in spermatogonia of CBA male mice which were thrice gamma-irradiated at doses of 300 r with 28 days intervals. The rate of induced recessive lethals was estimated 1) by comparison of embryos survival between the irradiated and control groups in mating of the F1 males with their daughters, and 2) by estimation the frequency of males heterozygotes for recessive lethals in the first generation. In the first case the frequency of recessive lethals was 2,8 +/- 0,8-10(-4) per r per gamete (for the pre- and post-implantation death) and 1,6 +/- 0,1-10(-4) per r per gamete (for the pre- and post-implantation death) and 1,6 +/- 0,1-10(-4) per r per gamete in the second case. The frequency of heterozygotes for reciprocal translocations in the first generations of males was 3,1 +/- 0,9-10(-5) per r per gamete.
对CBA雄性小鼠的精原细胞中隐性致死突变和相互易位的频率进行了研究，这些小鼠以300伦琴的剂量进行了三次γ射线照射，间隔28天。诱导隐性致死率的估计方法如下：1）通过比较F1雄性小鼠与其女儿交配时照射组和对照组胚胎的存活率；2）通过估计第一代中隐性致死杂合子雄性的频率。在第一种情况下，隐性致死频率为每伦琴每配子2.8±0.8×10⁻⁴（针对植入前和植入后死亡），在第二种情况下为每伦琴每配子1.6±0.1×10⁻⁴。第一代雄性中相互易位杂合子的频率为每伦琴每配子3.1±0.9×10⁻⁵。
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