Ushida T, Tani T, Kawasaki M, Iwatsu O, Yamamoto H
Department of Orthopaedic Surgery, Kochi Medical School, Japan.
Neurosci Lett. 1999 Jan 29;260(2):89-92. doi: 10.1016/s0304-3940(98)00968-9.
Due to the discovery of peripheral N-methyl-D-aspartate (NMDA) receptors, the effects of peripherally administrated MK-801, a non-competitive NMDA receptor antagonist, and phosphate buffered saline were tested by using the response changes of wide-dynamic range cells in the lumbar enlargement of the spinal cord in Sprague-Dawley rats. MK-801 (1 microM, 50 microl) administered directly into the subcutaneous tissue of the receptive field (n = 7), produces a reversible reduction of responses to noxious and innocuous stimuli by a peripheral action. There was no change in the responses to cutaneous stimuli following injection of phosphate buffered saline (n = 7) or following administration of MK-801 into the contralateral foot (n = 7). The present study suggests that MK-801 produces a local anesthetic like effect in the peripheral tissue.
由于外周N-甲基-D-天冬氨酸（NMDA）受体的发现，通过使用Sprague-Dawley大鼠脊髓腰膨大处广动力范围细胞的反应变化，测试了外周给予非竞争性NMDA受体拮抗剂MK-801和磷酸盐缓冲盐水的效果。将MK-801（1微摩尔，50微升）直接注射到感受野的皮下组织（n = 7），通过外周作用对有害和无害刺激的反应产生可逆性降低。注射磷酸盐缓冲盐水（n = 7）后或对侧足部给予MK-801（n = 7）后，对皮肤刺激的反应没有变化。本研究表明，MK-801在外周组织中产生类似局部麻醉的作用。
