Genoni M, Jenni R, Hoerstrup S P, Vogt P, Turina M
Clinic for Cardiovascular Surgery, University Hospital, Zurich, Switzerland.
Heart. 1999 Mar;81(3):276-7. doi: 10.1136/hrt.81.3.276.
To investigate the risk of pregnancy in patients with transposition of the great arteries (TGA) who have undergone atrial repair.
Retrospective analysis (1962-94) of 342 TGA patients who underwent atrial repair. Of 231 known late survivors, 48 were women over 18 years old who were interviewed about possible reproductive plans and previous pregnancies. As a control, comparison was made with data of 57 500 women (mean age 26 years) obtained from the Swiss Statistical Bank in Bern.
Mean follow up was 13.7 years; 66% remained asymptomatic, 29% had mild to moderate cardiac symptoms, and 5% suffered from severe cardiac symptoms (New York Heart Association grade III-IV). Thirty six of the 48 women wished to bear children and, to date, there have been 10 live births, two spontaneous first trimester abortions, and one induced abortion at 16 weeks. During pregnancy there was one case of cardiac deterioration and two cases of pneumonia. There was no evidence of congenital heart disease in the children.
In this relatively small series the completion of pregnancy in women with TGA who had undergone atrial repair and who had normal functional cardiac status was uncomplicated
研究接受心房修复术的大动脉转位（TGA）患者的妊娠风险。
对342例接受心房修复术的TGA患者进行回顾性分析（1962 - 1994年）。在231名已知的晚期存活者中，48名是18岁以上的女性，就其可能的生育计划和既往妊娠情况进行了访谈。作为对照，与从伯尔尼瑞士统计局获得的57500名女性（平均年龄26岁）的数据进行了比较。
平均随访13.7年；66%无症状，29%有轻至中度心脏症状，5%有严重心脏症状（纽约心脏协会III - IV级）。48名女性中有36名希望生育，迄今为止，有10例活产，2例孕早期自然流产，1例16周时人工流产。孕期有1例心脏功能恶化，2例肺炎。儿童中无先天性心脏病证据。
在这个相对较小的系列研究中，接受心房修复术且心脏功能正常的TGA女性完成妊娠过程无并发症。
