Henneberger P K, Lax M B
Central New York Occupational Health Clinical Center, 6712 Brooklawn Parkway, Suite 204, Syracuse, NY 13211, USA.
Int J Occup Environ Health. 1998 Jul-Sep;4(3):147-54. doi: 10.1179/oeh.1998.4.3.147.
The occurrence of deaths due to lung cancer was studied among 883 white male workers from a pulp and paper company in northern New Hampshire. All subjects had participated in a longitudinal study of respiratory morbidity, and data from interviews were used to construct lifetime cigarette smoking and occupational histories. Most of the subjects had entered follow-up in the 1960s and, at that time, their mean age was 51 years and they had worked for the pulp and paper company a mean of 25 years. By the end of follow-up in 1992, the 512 deceased subjects included 35 whose underlying cause of death had been lung cancer. With an internal comparison using the Cox proportional-hazards model, the hazard ratio for sulfite pulp mill work was 2.5 (95% CI 1.3-4.9), while controlling for the effects of age, cigarette smoking, and work in other parts of the pulping operation. In addition, the hazard ratio for the combination of >35 pack-years of smoking and >10 years sulfite mill work was greater than the product of the hazard ratios for each factor alone. While these findings are consistent with past asbestos exposure in the sulfite pulp mill environment, the absence of mesothelioma cases is inconsistent with this type of exposure.
在新罕布什尔州北部一家纸浆和造纸公司的883名白人男性工人中，对肺癌死亡情况进行了研究。所有受试者都参与了一项关于呼吸道发病率的纵向研究，访谈数据被用于构建终生吸烟史和职业史。大多数受试者于20世纪60年代开始随访，当时他们的平均年龄为51岁，在纸浆和造纸公司工作的平均年限为25年。到1992年随访结束时，512名已故受试者中有35人死于肺癌。使用Cox比例风险模型进行内部比较时，在控制年龄、吸烟以及制浆操作其他环节工作影响的情况下，亚硫酸盐制浆厂工作的风险比为2.5（95%可信区间1.3 - 4.9）。此外，吸烟超过35包年且在亚硫酸盐制浆厂工作超过10年的联合风险比大于各因素单独风险比的乘积。虽然这些发现与过去在亚硫酸盐制浆厂环境中接触石棉的情况一致，但未出现间皮瘤病例与这种接触情况不符。
