Wong E, Guyatt G H, Cook D J, Griffith L E, Irvine E J
Department of Medicine, University of Alberta, Edmonton, Canada.
Eur J Surg Suppl. 1998(583):50-6. doi: 10.1080/11024159850191247.
To develop a questionnaire for measuring health-related quality of life (HRQL) in patients with Irritable Bowel Syndrome (IBS).
We surveyed the existing literature, and interviewed patients and clinicians, to develop a list of 182 potential problems for IBS patients. One hundred patients with IBS completed a questionnaire in which they told us whether each of the 182 items was a problem for them, and if so the magnitude of their importance in their lives.
Patients identified four major problem areas: bowel symptoms, fatigue, activity limitations, and emotional dysfunction. On the basis of these findings, we constructed a 26-item questionnaire which, in pre-testing, 16 patients found clear and easy to complete.
We have developed a questionnaire that measures HRQL in IBS patients and is suitable for use as an outcome measure in clinical trials in IBS.
编制一份用于测量肠易激综合征（IBS）患者健康相关生活质量（HRQL）的问卷。
我们查阅了现有文献，并采访了患者和临床医生，以列出182个IBS患者可能存在的问题。100名IBS患者完成了一份问卷，在问卷中他们告知我们这182个项目中的每一项是否是他们面临的问题，如果是，该问题在他们生活中的重要程度。
患者确定了四个主要问题领域：肠道症状、疲劳、活动受限和情绪功能障碍。基于这些发现，我们编制了一份包含26个条目的问卷，在预测试中，16名患者认为该问卷清晰且易于填写。
我们编制了一份可测量IBS患者HRQL的问卷，适用于作为IBS临床试验的结局指标。
