Beck P L, Podolsky D K
Department of Medicine, Massachusetts General Hospital 02114, USA.
Inflamm Bowel Dis. 1999 Feb;5(1):44-60. doi: 10.1097/00054725-199902000-00007.
The pathogenesis of both ulcerative colitis and Crohn's disease is unknown but these forms of inflammatory bowel disease (IBD) may be associated with an inability of the intestinal mucosa to protect itself from luminal challenges and/or inappropriate repair following intestinal injury. Numerous cell populations regulate these broad processes through the expression of a complex array of peptides and other agents. Growth factors can be distinguished by their actions regulating cell proliferation. These factors also mediate processes such as extracellular matrix formation, cell migration and differentiation, immune regulation, and tissue remodeling. Several families of growth factors may play an important role in IBD including: epidermal growth factor family (EGF) [transforming growth factor alpha (TGF alpha), EGF itself, and others], the transforming growth factor beta (TGF beta) super family, insulin-like growth factors (IGF), fibroblast growth factors (FGF), hepatocyte growth factor (HGF), trefoil factors, platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and others. Collectively these families may determine susceptibility of IBD mucosa to injury and facilitate tissue repair.
溃疡性结肠炎和克罗恩病的发病机制尚不清楚，但这些炎症性肠病（IBD）形式可能与肠黏膜无法保护自身免受肠腔刺激和/或肠道损伤后不适当的修复有关。众多细胞群体通过表达一系列复杂的肽和其他因子来调节这些广泛的过程。生长因子可根据其调节细胞增殖的作用来区分。这些因子还介导诸如细胞外基质形成、细胞迁移和分化、免疫调节以及组织重塑等过程。几个生长因子家族可能在IBD中起重要作用，包括：表皮生长因子家族（EGF）[转化生长因子α（TGFα）、EGF本身及其他成员]、转化生长因子β（TGFβ）超家族、胰岛素样生长因子（IGF）、成纤维细胞生长因子（FGF）、肝细胞生长因子（HGF）、三叶因子、血小板衍生生长因子（PDGF）、血管内皮生长因子（VEGF）等。这些家族共同作用可能决定IBD黏膜对损伤的易感性并促进组织修复。
