Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Inflamm Bowel Dis. 2011 Jan;17(1):410-22. doi: 10.1002/ibd.21316.
A key feature of inflammatory bowel disease (IBD) is impaired epithelial repair. Human growth factors comprise an array of signaling molecules that lead to ligand-specific signal transduction. Their downstream effects are associated with several cellular functions including epithelial healing in response to injury. Several studies have described specific growth factor deficiencies in patients with IBD, implicating their role in disease pathophysiology. The aim of this review was to describe currently known enterocyte-targeted growth factors, their mechanisms of action, and their potential therapeutic utility.
The National Library of Medicine (http://www.pubmed.gov) and meeting abstracts were searched using the following terms: growth factor, intestine, colon, inflammatory bowel disease, Crohn's disease, ulcerative colitis, colitis, animal model, transforming growth factor, bone morphogenetic protein, activins, growth hormone, fibroblast growth factor, epidermal growth factor (EGF), keratinocyte growth factor (KGF), glucagon-like peptide II, granulocyte macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), vascular endothelial growth factor (VEGF) inhibitors, and trefoil factors.
Several growth factors are therapeutic candidates in IBD. Growth hormone, KGF, EGF, teduglutide, GM-CSF/G-CSF have entered early clinical trials, whereas others are currently in preclinical evaluation.
There are several growth factors responsible for epithelial repair. Preliminary studies using recombinant growth factors seem promising in IBD preclinical and clinical trials.
炎症性肠病 (IBD) 的一个主要特征是上皮修复受损。人类生长因子包含一系列信号分子，这些分子会导致配体特异性信号转导。它们的下游效应与多种细胞功能相关，包括上皮细胞在受到损伤后的愈合。多项研究描述了 IBD 患者中特定生长因子的缺乏，表明它们在疾病发病机制中发挥作用。本综述旨在描述目前已知的肠细胞靶向生长因子、它们的作用机制及其潜在的治疗用途。
使用以下术语在国家医学图书馆 (http://www.pubmed.gov) 和会议摘要中进行检索：生长因子、肠、结肠、炎症性肠病、克罗恩病、溃疡性结肠炎、结肠炎、动物模型、转化生长因子、骨形态发生蛋白、激活素、生长激素、成纤维细胞生长因子、表皮生长因子 (EGF)、角质细胞生长因子 (KGF)、胰高血糖素样肽 II、粒细胞巨噬细胞集落刺激因子 (GM-CSF)、粒细胞集落刺激因子 (G-CSF)、血管内皮生长因子 (VEGF) 抑制剂和三叶因子。
有几种生长因子是 IBD 的治疗候选物。生长激素、KGF、EGF、特利格鲁肽、GM-CSF/G-CSF 已进入早期临床试验，而其他生长因子则正在进行临床前评估。
有几种生长因子负责上皮修复。使用重组生长因子的初步研究在 IBD 的临床前和临床试验中似乎很有前景。
