Jin L, Sun Y J, Ge L, Brown D W
Enteric and Respiratory virus Laboratory, Central Public Health Laboratory, London, UK.
Epidemiol Infect. 1998 Dec;121(3):691-7. doi: 10.1017/s0950268898001666.
We report the co-circulation of a new lineage of measles virus (MV) and an Edmonston-like (Ed-like) genotype of MV in China during 1995-7. Sequence analysis of 25 strains was performed on a 282 nucleotides (nt) region of the nucleoprotein (N) gene, a 450-nt region of the haemagglutinin (H) gene and a 152-nt region of the matrix (M) gene by direct sequencing of RT-PCR amplicons obtained from clinical specimens. The entire H gene was sequenced from two strains. The results showed that 24/25 Chinese strains belonged to a new genogroup and were distinct from the vaccine strains used in China and the UK, and also from MV strains previously described in Europe, Africa and the USA. The remaining strain was Ed-like. Two strains of the new genotype (IV) and one of the Ed-like genotype were also detected in the UK in 1996.
我们报告了1995年至1997年期间中国境内一种新型麻疹病毒（MV）谱系与一种埃德蒙斯顿样（Ed样）MV基因型共同传播的情况。通过对从临床标本中获得的逆转录聚合酶链反应（RT-PCR）扩增产物进行直接测序，对25株病毒的核蛋白（N）基因的282个核苷酸（nt）区域、血凝素（H）基因的450 nt区域和基质（M）基因的152 nt区域进行了序列分析。对两株病毒的整个H基因进行了测序。结果显示，24/25的中国毒株属于一个新的基因群，与中国和英国使用的疫苗毒株不同，也与先前在欧洲、非洲和美国描述的MV毒株不同。其余毒株为Ed样。1996年在英国也检测到了两株新型基因型（IV）毒株和一株Ed样基因型毒株。
