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精神变化作为多发性硬化症的早期特征。

Mental change as an early feature of multiple sclerosis.

作者信息

Young A C, Saunders J, Ponsford J R

出版信息

J Neurol Neurosurg Psychiatry. 1976 Oct;39(10):1008-13. doi: 10.1136/jnnp.39.10.1008.

DOI:10.1136/jnnp.39.10.1008
PMID:1003237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC492505/
Abstract

Five patients with mental change as a prominent and early feature of an illness which appeared to be multiple sclerosis are reported. All the patients had in addition clinical signs of predominant brain stem involvement and the cerebrospinal fluid findings were similar. It is emphasised that mental change may be an early feature of multiple sclerosis even in those patients in whom the onset of the disease is insidious.

摘要

报告了5例以精神改变为突出且早期特征的疾病患者,该疾病似乎为多发性硬化症。所有患者还伴有以脑干受累为主的临床体征,且脑脊液检查结果相似。需要强调的是,即使在疾病起病隐匿的患者中,精神改变也可能是多发性硬化症的早期特征。

相似文献

1
Mental change as an early feature of multiple sclerosis.精神变化作为多发性硬化症的早期特征。
J Neurol Neurosurg Psychiatry. 1976 Oct;39(10):1008-13. doi: 10.1136/jnnp.39.10.1008.
2
Searching for neurodegeneration in multiple sclerosis at clinical onset: Diagnostic value of biomarkers.在多发性硬化症的临床发病期寻找神经退行性变:生物标志物的诊断价值。
PLoS One. 2018 Apr 3;13(4):e0194828. doi: 10.1371/journal.pone.0194828. eCollection 2018.
3
[Early detection of multiple sclerosis: MR findings in the initial manifestations of multiple sclerosis].[多发性硬化的早期检测:多发性硬化初始表现的磁共振成像结果]
Rofo. 1988 Jul;149(1):63-8. doi: 10.1055/s-2008-1048297.
4
[Laboratory diagnosis of multiple sclerosis].[多发性硬化症的实验室诊断]
Tidsskr Nor Laegeforen. 1991 Aug 10;111(18):2267-70.
5
Tumor-like multiple sclerosis.肿瘤样多发性硬化症。
Acta Clin Croat. 2012 Mar;51(1):113-6.
6
Multiple sclerosis showing elevation of adenosine deaminase levels in the cerebrospinal fluid.多发性硬化症患者脑脊液中腺苷脱氨酶水平升高。
Mult Scler Relat Disord. 2017 Apr;13:44-46. doi: 10.1016/j.msard.2017.02.005. Epub 2017 Feb 6.
7
Multiple sclerosis presenting as chronic atypical psychosis.表现为慢性非典型精神病的多发性硬化症。
J Neurol Neurosurg Psychiatry. 1988 Feb;51(2):281-4. doi: 10.1136/jnnp.51.2.281.
8
A second case of Marburg's variant of multiple sclerosis with vasculitis and extensive demyelination.又一例马尔堡变异型多发性硬化症合并血管炎和广泛脱髓鞘。
Mult Scler. 2011 Dec;17(12):1531-8. doi: 10.1177/1352458511414042. Epub 2011 Aug 3.
9
[Symptomatic dementia syndrome of multiple sclerosis].[多发性硬化症的症状性痴呆综合征]
Riv Neurol. 1982 Jan-Feb;52(1):24-32.
10
[Syringomyelia, a neglected differential diagnosis in multiple sclerosis. 6 cases from a specialty clinic for multiple sclerosis].
Nervenarzt. 1995 Aug;66(8):630-3.

引用本文的文献

1
Isolated progressive cognitive impairment and depression in a patient with neuroradiological features suggestive of multiple sclerosis.患者具有提示多发性硬化症的神经影像学特征,表现为孤立性进行性认知障碍和抑郁。
Neurol Sci. 2011 Aug;32(4):695-7. doi: 10.1007/s10072-011-0581-9. Epub 2011 Apr 16.
2
Cognitive presentation of multiple sclerosis: evidence for a cortical variant.多发性硬化的认知表现:皮质变异型的证据。
J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):872-7. doi: 10.1136/jnnp.74.7.872.
3
The neuropsychology of multiple sclerosis: contributions of neuroimaging research.
Curr Psychiatry Rep. 2001 Oct;3(5):373-8. doi: 10.1007/s11920-996-0029-8.
4
Multiple sclerosis and psychiatric disturbances: clinical aspects and a review of the literature.多发性硬化症与精神障碍:临床方面及文献综述
Ital J Neurol Sci. 1996 Jun;17(3):189-91. doi: 10.1007/BF01995682.
5
Dementia in two histologically confirmed cases of multiple sclerosis: one case with isolated dementia and one case associated with psychiatric symptoms.两例经组织学确诊的多发性硬化症患者出现痴呆:一例为单纯性痴呆,另一例伴有精神症状。
J Neurol Neurosurg Psychiatry. 1994 Mar;57(3):353-9. doi: 10.1136/jnnp.57.3.353.
6
Depression as a major symptom of multiple sclerosis.抑郁症作为多发性硬化症的主要症状。
J Neurol Neurosurg Psychiatry. 1980 Oct;43(10):861-5. doi: 10.1136/jnnp.43.10.861.
7
Atypical and clinically silent multiple sclerosis: a report of 12 cases discovered unexpectedly at necropsy.非典型及临床无症状性多发性硬化症:12例尸检意外发现病例报告
J Neurol Neurosurg Psychiatry. 1983 May;46(5):414-20. doi: 10.1136/jnnp.46.5.414.
8
Decline of cognition in multiple sclerosis: dissociable deficits.多发性硬化症中的认知衰退:可分离的缺陷。
J Neurol Neurosurg Psychiatry. 1986 Dec;49(12):1354-60. doi: 10.1136/jnnp.49.12.1354.
9
A case of multiple sclerosis with an onset mimicking the Kleine-Levin syndrome.一例起病类似克莱恩-莱文综合征的多发性硬化症病例。
Ital J Neurol Sci. 1987 Apr;8(2):151-5. doi: 10.1007/BF02337589.
10
Depression and neuroticism in multiple sclerosis.
Ital J Neurol Sci. 1988 Dec;9(6):551-7. doi: 10.1007/BF02337008.

本文引用的文献

1
The pathology of multiple sclerosis.多发性硬化症的病理学
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2
A clinico-experimental investigation into the psychologic aspects of multiple sclerosis.对多发性硬化症心理方面的临床实验研究。
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3
An investigation of the psychiatric aspects of disseminated sclerosis.播散性硬化症的精神方面调查。
J Neurol Neurosurg Psychiatry. 1951 Nov;14(4):326-35. doi: 10.1136/jnnp.14.4.326.
4
Intellectual and affective functions in multiple sclerosis; a quantitative study.多发性硬化症中的智力和情感功能;一项定量研究。
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A CASE OF PRESENILE FULMINATING MULTIPLE SCLEROSIS (WITH PATHOGENIC CONSIDERATIONS).一例早发性暴发性多发性硬化症(附病因探讨)
Confin Neurol. 1964;24:417-24. doi: 10.1159/000104134.
6
[Acute multiple sclerosis with hypothalamic lozalization with melancholic symptomatology].[伴有下丘脑定位及抑郁症状的急性多发性硬化症]
Riv Neurol. 1961 May-Jun;31:240-68.
7
[Multiple sclerosis with onset by mental disorders. Anatomo-clinical study].[伴精神障碍起病的多发性硬化症。解剖临床研究]
Rev Neurol (Paris). 1959 Jul;101:45-51.
8
Impairment of abstracting ability in multiple sclerosis.多发性硬化症中抽象能力的损害。
J Nerv Ment Dis. 1957 Apr-Jun;125(2):221-5. doi: 10.1097/00005053-195704000-00007.
9
Disseminated sclerosis presenting as schizophrenia.以精神分裂症为表现的播散性硬化症。
Med J Aust. 1956 Mar 10;43(10):405-7.
10
Severe mental symptoms in disseminated sclerosis, a neuro-pathological study.播散性硬化症中的严重精神症状:一项神经病理学研究
J Ir Med Assoc. 1966 Apr;58(346):115-27.