Patsch W, Lisch H J, Sailer S, Braunsteiner H
Eur J Clin Invest. 1978 Aug;8(4):209-13. doi: 10.1111/j.1365-2362.1978.tb00854.x.
The initial cholesterol esterification rate (LCAT activity) was determined in ninety-four hyperlipidaemic subjects. LCAT activity was elevated in hypertriglyceridaemia, whereas patients with hypercholesterolaemia had normal activities. In hypertriglyceridaemic subjects LCAT activity correlated with the concentrations of d less than 1.006 lipoproteins, plasma triglycerides, cholesterol and cholesterol esters and phospholipid levels. Addition of d less than 1.006 lipoprotein to normal plasma resulted in a dose dependent stimulation of enzyme activity with a sigmoidal response curve. When the d less than 1.006 lipoproteins were removed from hypertriglyceridaemic plasma by ultracentrifugation, the enzyme activity in the residual d greater than 1.006 fraction dropped, but still was higher than in normal plasma and correlated with the amount of d less than 1.006 lipoproteins originally present. Thus, high LCAT activity in hypertriglyceridaemia cannot be explained solely by the presence of an increased d less than 1.006 lipoprotein concentration. An increase of enzyme concentration or changes in concentration or composition of other lipoproteins (high density lipoproteins) may contribute to the high LCAT activity in hypertriglyceridaemia.
在94名高脂血症患者中测定了初始胆固醇酯化率（卵磷脂胆固醇酰基转移酶活性）。在高甘油三酯血症中，卵磷脂胆固醇酰基转移酶活性升高，而高胆固醇血症患者的活性正常。在高甘油三酯血症患者中，卵磷脂胆固醇酰基转移酶活性与密度小于1.006的脂蛋白、血浆甘油三酯、胆固醇、胆固醇酯及磷脂水平的浓度相关。向正常血浆中添加密度小于1.006的脂蛋白会导致酶活性呈剂量依赖性刺激，呈现S形反应曲线。当通过超速离心从高甘油三酯血症血浆中去除密度小于1.006的脂蛋白时，剩余密度大于1.006部分的酶活性下降，但仍高于正常血浆，且与最初存在的密度小于1.006的脂蛋白量相关。因此，高甘油三酯血症中高卵磷脂胆固醇酰基转移酶活性不能仅通过密度小于1.006的脂蛋白浓度增加来解释。酶浓度的增加或其他脂蛋白（高密度脂蛋白）浓度或组成的变化可能导致高甘油三酯血症中高卵磷脂胆固醇酰基转移酶活性。
