Goren R, Simons L A
Clin Chim Acta. 1977 Feb 1;74(3):289-96. doi: 10.1016/0009-8981(77)90296-0.
Plasma cholesterol esterification was assessed in hypertriglyceridaemic patients and normal subjects by two in vitro methods, one using autologous substrate and one using exogenous substrate. There was a significant negative correlation between cholesterol esterification rate and the plasma triglyceride concentration when this was assessed with autologous substrate or with substrate from a hypertriglyceridaemic donor. The percentage of esterified cholesterol in plasma and the esterification rate were always reduced when the plasma triglyceride concentration exceeded 7 mmol/1 and the rate of esterification rose significantly with appropriate triglyceride-lowering therapy in such patients. Evidence is presented that the impaired cholesterol esterification observed in severe hypertriglyceridaemia is secondary to a reduced concentration of substrate high density lipoprotein cholesterol, as well as to an excess of large triglyceride-rich lipoproteins.
通过两种体外方法对高甘油三酯血症患者和正常受试者的血浆胆固醇酯化进行了评估，一种方法使用自体底物，另一种使用外源性底物。当使用自体底物或来自高甘油三酯血症供体的底物评估时，胆固醇酯化率与血浆甘油三酯浓度之间存在显著的负相关。当血浆甘油三酯浓度超过7 mmol/1时，血浆中酯化胆固醇的百分比和酯化率总是降低的，并且在这类患者中，适当的降甘油三酯治疗可使酯化率显著升高。有证据表明，在严重高甘油三酯血症中观察到的胆固醇酯化受损继发于底物高密度脂蛋白胆固醇浓度降低以及富含甘油三酯的大脂蛋白过量。
