Singer G M, Taylor H W
J Natl Cancer Inst. 1976 Dec;57(6):1275-6. doi: 10.1093/jnci/57.6.1275.
N'-Nitrosonornicotine was added to the drinking water of outbred Sprague-Dawley rats. Adenocarcinomas of the olfactory epithelium occurred in all 15 rats, squamous papillomas o- the esophagus in 1, squamous papillomas of the nonglandular stomach in 1, and a hepatacellular tumor in 1. The possible ingestion and subsequent in vivo nitrosation of nicotine and/or nornicotine could create a serious carcinogenic hazard to cigarette smokers.
将N'-亚硝基降烟碱添加到远交群斯普拉格-道利大鼠的饮用水中。所有15只大鼠均发生了嗅上皮腺癌，1只出现食管鳞状乳头瘤，1只出现非腺胃鳞状乳头瘤，1只出现肝细胞肿瘤。尼古丁和/或降烟碱可能的摄入以及随后在体内的亚硝化作用可能会对吸烟者造成严重的致癌风险。
