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双戊霉素，一种由灰黄链霉菌MK393 - AF2产生的新型抗微生物抗生素。I. 分类学、发酵、分离、理化性质及生物活性。

Diperamycin, a new antimicrobial antibiotic produced by Streptomyces griseoaurantiacus MK393-AF2. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.

作者信息

Matsumoto N, Momose I, Umekita M, Kinoshita N, Chino M, Iinuma H, Sawa T, Hamada M, Takeuchi T

机构信息

Institute of Microbial Chemistry, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1998 Dec;51(12):1087-92. doi: 10.7164/antibiotics.51.1087.

DOI:10.7164/antibiotics.51.1087
PMID:10048567
Abstract

Antibacterial antibiotics, diperamycin (1) was produced in the culture broth of Streptomyces griseoaurantiacus MK393-AF2. Various spectroscopic analyses of 1 suggested that 1 belonged to a member of cyclic hexadepsipeptide antibiotic. Antibiotic 1 had potent inhibitory activity against various Gram-positive bacteria including Enterococcus seriolicida and methicillin-resistant Staphylococcus aureus.

摘要

作为一种抗菌抗生素，双霉素（1）由灰黄橙链霉菌MK393-AF2的发酵液产生。对1的各种光谱分析表明，1属于环六缩肽抗生素家族成员。抗生素1对包括杀鱼肠球菌和耐甲氧西林金黄色葡萄球菌在内的多种革兰氏阳性菌具有强大的抑制活性。

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