UK-1，一种来自链霉菌属517-02的新型细胞毒性代谢产物。I. 分类学、发酵、分离、物理化学及生物学特性

UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties.

作者信息

Ueki M, Ueno K, Miyadoh S, Abe K, Shibata K, Taniguchi M, Oi S

机构信息

Faculty of Science, Osaka City University, Japan.

出版信息

J Antibiot (Tokyo). 1993 Jul;46(7):1089-94. doi: 10.7164/antibiotics.46.1089.

DOI:10.7164/antibiotics.46.1089

Abstract

A new benzoxazole, UK-1, was isolated from the mycelial cake of an actinomycete strain 517-02. Based on morphological, cultural and physiological characteristics, strain 517-02 was seemed to be a close relative of Streptomyces morookaense. UK-1 showed potent cytotoxic activity against B16, HeLa and P388 cells and did not show any antimicrobial activity.

摘要

一种新的苯并恶唑类化合物UK-1，是从一株放线菌菌株517-02的菌丝体饼中分离得到的。根据形态学、培养和生理学特征，菌株517-02似乎是茂木链霉菌的近亲。UK-1对B16、HeLa和P388细胞显示出强大的细胞毒性活性，且未显示出任何抗菌活性。

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