Baenziger O, Mueller A M, Morales C G, Jaggi J L, Duc G, von Siebenthal K, Bucher H U
Department of Neonatology, University Hospital, Zurich, Switzerland.
Eur J Pediatr. 1999 Feb;158(2):138-43. doi: 10.1007/s004310051034.
Cerebral blood flow (CBF) studies have provided some insight into pathophysiological mechanisms of cerebral damage in newborn children; their value in predicting brain damage, however, remains elusive. The purpose of our study was to evaluate the role of CBF measurements in predicting developmental outcome in preterm neonates at 18 months. Preterm babies with a gestational age of less than 34 weeks and a birth weight of less than 1500 g (n = 71) were enrolled in the study. CBF was measured by the noninvasive intravenous 133Xe method on three different occasions. We classified our measurements into three groups: depending on the time when performed group 1: between 2 and 36 h (n = 52); group 2: between 36 and 108 h (n = 44); group 3: between 108 and 240 h (n = 41). At the age of 18 months neurodevelopment testing was performed according to the Bayley mental and motor scales. Surviving infants had a higher mean CBF over the three groups than non surviving children (15.2 +/- 3.5 ml/100 g brain tissue/min vs 13.0 +/- 2.1 ml/100 g brain tissue/min, P < 0.05). There was no correlation of CBF with mental or motor development in our study population in either of the three groups.
In preterm infants basal CBF is higher in surviving than in non surviving infants, but there is no correlation of resting CBF and later neurological outcome.
脑血流量（CBF）研究为新生儿脑损伤的病理生理机制提供了一些见解；然而，其在预测脑损伤方面的价值仍不明确。我们研究的目的是评估CBF测量在预测早产新生儿18个月时发育结局中的作用。纳入研究的是胎龄小于34周、出生体重小于1500g的早产儿（n = 71）。通过无创静脉注射133Xe方法在三个不同时间点测量CBF。我们将测量结果分为三组：根据测量时间，第1组：在2至36小时之间（n = 52）；第2组：在36至108小时之间（n = 44）；第3组：在108至240小时之间（n = 41）。在18个月时，根据贝利智力和运动量表进行神经发育测试。存活婴儿在三组中的平均CBF高于未存活儿童（15.2±3.5ml/100g脑组织/分钟对13.0±（此处原文可能有误，推测为2.1）2.1ml/100g脑组织/分钟，P < 0.05）。在我们的研究人群中，三组中的任何一组中CBF与智力或运动发育均无相关性。
在早产儿中，存活婴儿的基础CBF高于未存活婴儿，但静息CBF与后期神经学结局无相关性。
