Baenziger O, Jaggi J L, Mueller A C, Morales C G, Lipp A E, Duc G, Bucher H U
University Children's Hospital, Zurich, Switzerland.
Eur J Pediatr. 1995 Nov;154(11):919-24. doi: 10.1007/BF01957506.
The purpose of our study was to evaluate the regional distribution of the resting cerebral blood flow (CBF) pattern in preterm neonates. Sixty-eight preterm babies with a gestational age of less than 34 weeks and a birth weight of less than 1500 g were enrolled into the study. The CBF was measured by the noninvasive intravenous 133Xenon method at three different times. Depending on the age we classified our measurements into three groups. Group 1: measurement between 2-36 h (n = 46). Group 2: measurement between 36-108 h (n = 39). Group 3: measurement between 108-240 h (n = 41). In all three groups CBF was significantly lower in the occipital region than in the frontal and parietal regions (group 1: frontal region 12.8 +/- 3.5 ml/100 g/min, parietal region 12.8 +/- 3.9 ml/100 mg/min, and occipital region 11.6 +/- 3.18 ml/100 g/min; group 2: frontal region 15.4 +/- 4.2 ml/100 g/min, parietal region 15.3 +/- 4.1 ml/100 g/min, and occipital region 13.4 +/- 3.5 ml/100 g/min; group 3: frontal region 14.6 +/- 3.6 ml/100 g/min, parietal region 14.6 +/- 3.2 ml/100 g/min, and occipital region 12.8 +/- 2.7 ml/100 g/min.). CBF did not differ between the left and the right hemispheres in either of the three measured regions. No gradient was found in infants between 108 h and 240 h of age with periventricular leukomalacia and periventricular haemorrhage. CONCLUSION. In preterm neonates the antero-posterior gradient of CBF is already present. Periventricular leukomalacia as well as periventricular haemorrhage may affect the regional regulation of CBF.
我们研究的目的是评估早产儿静息脑血流（CBF）模式的区域分布。68例胎龄小于34周、出生体重小于1500克的早产儿被纳入研究。通过无创静脉注射133氙方法在三个不同时间测量CBF。根据年龄，我们将测量结果分为三组。第1组：在2至36小时之间测量（n = 46）。第2组：在36至108小时之间测量（n = 39）。第3组：在108至240小时之间测量（n = 41）。在所有三组中，枕叶区域的CBF均显著低于额叶和顶叶区域（第1组：额叶区域12.8±3.5毫升/100克/分钟，顶叶区域12.8±3.9毫升/100毫克/分钟，枕叶区域11.6±3.18毫升/100克/分钟；第2组：额叶区域15.4±4.2毫升/100克/分钟，顶叶区域15.3±4.1毫升/100克/分钟，枕叶区域13.4±3.5毫升/100克/分钟；第3组：额叶区域14.6±3.6毫升/100克/分钟，顶叶区域14.6±3.2毫升/100克/分钟，枕叶区域12.8±2.7毫升/100克/分钟）。在三个测量区域中的任何一个区域，左右半球之间的CBF均无差异。在108小时至240小时龄患有脑室周围白质软化症和脑室周围出血的婴儿中未发现梯度变化。结论。在早产儿中，CBF的前后梯度已经存在。脑室周围白质软化症以及脑室周围出血可能会影响CBF的区域调节。
