磷霉素可改变小鼠体内脂多糖诱导的炎性细胞因子生成。
Fosfomycin alters lipopolysaccharide-induced inflammatory cytokine production in mice.
作者信息
Matsumoto T, Tateda K, Miyazaki S, Furuya N, Ohno A, Ishii Y, Hirakata Y, Yamaguchi K
机构信息
Department of Microbiology, Toho University School of Medicine, Tokyo, Japan.
出版信息
Antimicrob Agents Chemother. 1999 Mar;43(3):697-8. doi: 10.1128/AAC.43.3.697.
Abstract
To determine the mechanisms of immunomodulating action of fosfomycin (FOF), we examined its effect on the production of inflammatory cytokines in mice injected with lipopolysaccharide (LPS). Treatment with FOF significantly lowered the peak serum levels of tumor necrosis factor alpha and interleukin-1 beta, indicating that FOF alters inflammatory cytokine production after LPS stimulation.
摘要
为了确定磷霉素（FOF）免疫调节作用的机制，我们检测了其对注射脂多糖（LPS）小鼠体内炎性细胞因子产生的影响。用FOF治疗可显著降低肿瘤坏死因子α和白细胞介素-1β的血清峰值水平，表明FOF可改变LPS刺激后炎性细胞因子的产生。
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本文引用的文献
1
Paradoxical synergistic effects of tumour necrosis factor and interleukin 1 in murine gut-derived sepsis with Pseudomonas aeruginosa.肿瘤坏死因子与白细胞介素-1在小鼠铜绿假单胞菌肠道源性脓毒症中的矛盾协同效应
Cytokine. 1999 May;11(5):366-72. doi: 10.1006/cyto.1998.0434.
2
Efficacies of alkaline protease, elastase and exotoxin A toxoid vaccines against gut-derived Pseudomonas aeruginosa sepsis in mice.碱性蛋白酶、弹性蛋白酶和外毒素A类毒素疫苗对小鼠肠道源性铜绿假单胞菌败血症的疗效。
J Med Microbiol. 1998 Apr;47(4):303-8. doi: 10.1099/00222615-47-4-303.
3
Adverse effects of tumour necrosis factor in cyclophosphamide-treated mice subjected to gut-derived Pseudomonas aeruginosa sepsis.肿瘤坏死因子在接受环磷酰胺治疗且遭受源自肠道的铜绿假单胞菌败血症的小鼠中的不良反应。
Cytokine. 1997 Oct;9(10):763-9. doi: 10.1006/cyto.1997.0222.
4
Immunomodulating effect of fosfomycin on gut-derived sepsis caused by Pseudomonas aeruginosa in mice.磷霉素对小鼠铜绿假单胞菌所致肠道源性败血症的免疫调节作用。
Antimicrob Agents Chemother. 1997 Feb;41(2):308-13. doi: 10.1128/AAC.41.2.308.
5
Modulatory effect of antibiotics on cytokine production by human monocytes in vitro.抗生素对人单核细胞体外细胞因子产生的调节作用。
Antimicrob Agents Chemother. 1996 Jun;40(6):1366-70. doi: 10.1128/AAC.40.6.1366.
6
Mortality rates amongst mice with endogenous septicaemia caused by Pseudomonas aeruginosa isolates from various clinical sources.由来自各种临床来源的铜绿假单胞菌分离株引起的内源性败血症小鼠的死亡率。
J Med Microbiol. 1993 Aug;39(2):141-6. doi: 10.1099/00222615-39-2-141.
7
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin.针对恶病质素/肿瘤坏死因子的被动免疫可保护小鼠免受内毒素的致死作用。
Science. 1985 Aug 30;229(4716):869-71. doi: 10.1126/science.3895437.
8
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia.抗恶病质素/肿瘤坏死因子单克隆抗体可预防致死性菌血症期间的感染性休克。
Nature. 1987;330(6149):662-4. doi: 10.1038/330662a0.
9
Sensitization and desensitization to lethal effects of tumor necrosis factor and IL-1.对肿瘤坏死因子和白细胞介素-1致死效应的致敏和脱敏作用。
J Immunol. 1988 May 1;140(9):2994-9.
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