促生存的Bcl-2同源物Bfl-1/A1是NF-κB的直接转录靶点，可阻断肿瘤坏死因子α诱导的细胞凋亡。
The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis.
作者信息
Zong W X, Edelstein L C, Chen C, Bash J, Gélinas C
机构信息
Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Jersey 08854-5638 USA.
出版信息
Genes Dev. 1999 Feb 15;13(4):382-7. doi: 10.1101/gad.13.4.382.
Abstract
Bcl-2-family proteins are key regulators of the apoptotic response. Here, we demonstrate that the pro-survival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB. We show that bfl-1 gene expression is dependent on NF-kappaB activity and that it can substitute for NF-kappaB to suppress TNFalpha-induced apoptosis. bfl-1 promoter analysis identified an NF-kappaB site responsible for its Rel/NF-kappaB-dependent induction. The expression of bfl-1 in immune tissues supports the protective role of NF-kappaB in the immune system. The activation of Bfl-1 may be the means by which NF-kappaB functions in oncogenesis and promotes cell resistance to anti-cancer therapy.
摘要
Bcl-2家族蛋白是细胞凋亡反应的关键调节因子。在此，我们证明促生存的Bcl-2同源物Bfl-1/A1是NF-κB的直接转录靶点。我们表明bfl-1基因表达依赖于NF-κB活性，并且它可以替代NF-κB来抑制TNFα诱导的细胞凋亡。bfl-1启动子分析确定了一个负责其Rel/NF-κB依赖性诱导的NF-κB位点。bfl-1在免疫组织中的表达支持了NF-κB在免疫系统中的保护作用。Bfl-1的激活可能是NF-κB在肿瘤发生中发挥作用并促进细胞对抗癌治疗产生抗性的方式。
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