[慢性炎症性肠病与妊娠。病例对照研究]

[Chronic inflammatory bowel disease and pregnancy. Case control study].

作者信息

Larzilliere I, Beau P

机构信息

Service d'Hépato-Gastroentérologie et Nutrition Artificielle, Hôpital Jean-Bernard, CHU, Poitiers.

出版信息

Gastroenterol Clin Biol. 1998 Dec;22(12):1056-60.

PMID:10051981

Abstract

OBJECTIVES

To evaluate the influence of inflammatory bowel disease on pregnancy and fetal outcome.

PATIENTS AND METHODS

One hundred and fifty pregnancies in 72 women (28 with ulcerative colitis and 44 with Crohn's disease) were compared with those of 150 control subjects.

RESULTS

Among 150 pregnancies, 108 (group I) began before and 42 (group II) at the same time or after the diagnosis of inflammatory bowel disease. In ulcerative colitis patients, age at first pregnancy, mean birth weight and preterm birth rates were not different between groups I and II; rate of underweight offsprings was significantly higher (P < 0.05) in group II than in group I and controls. In Crohn's disease, compared to group I, mean age of first pregnancy was higher (P < 0.0001), mean birth weight was lower (P < 0.005) and preterm birth rate was higher (P = 0.001) than in group II.

CONCLUSION

These results suggest that both ulcerative colitis and Crohn's disease induce deleterious effects on pregnancy and fetal outcome.

摘要

目的

评估炎症性肠病对妊娠及胎儿结局的影响。

患者与方法

将72名女性（28例溃疡性结肠炎患者和44例克罗恩病患者）的150次妊娠与150名对照者的妊娠情况进行比较。

结果

在150次妊娠中，108例（第一组）在炎症性肠病诊断前开始，42例（第二组）在诊断时或诊断后开始。在溃疡性结肠炎患者中，第一组和第二组的初孕年龄、平均出生体重和早产率无差异；第二组低体重儿的发生率显著高于第一组和对照组（P<0.05）。在克罗恩病患者中，与第一组相比，第二组的初孕平均年龄更高（P<0.0001），平均出生体重更低（P<0.005），早产率更高（P=0.001）。