Seyama Y, Hayashi M, Takegami H, Usami E
Department of Clinical Chemistry, Hoshi College of Pharmacy, Tokyo, Japan.
Int J Vitam Nutr Res. 1999 Jan;69(1):23-6. doi: 10.1024/0300-9831.69.1.23.
The comparative effects of vitamin K2 and vitamin E on aortic calcium (Ca) and inorganic phosphorus (P) levels in the aorta and the elastin fraction (fr.) were investigated in male rats after experimental arteriosclerosis was induced by vitamin D2 with atherogenic diet. Both vitamin K2 (100 mg/kg b.w.) and vitamin E (40 mg/kg b.w.) inhibited the increase of Ca and P in the aorta and the elastin fr. from the arteriosclerotic rats. Vitamin K2 (50 mg/kg b.w.) also suppressed the deposition of Ca and P in the aorta, but there was no change due to vitamin K3 or geranylgeraniol (side chain of vitamin K2) administration. Both vitamin K2 and vitamin E showed lipid radical scavenging activity in the in vitro experiment. However, neither vitamin K3 nor geranylgeraniol exhibited anti-arteriosclerotic or radical scavenging activity under the above experimental conditions. It is suggested that vitamin K2 and vitamin E promoted an antiarteriosclerotic effect by radical scavenging activity. These actions of vitamin K2 are required in the structure of 2-methylnaphtoquinone and its side chain (geranylgeraniol).
在通过给予致动脉粥样硬化饮食并补充维生素D2诱导雄性大鼠发生实验性动脉硬化后，研究了维生素K2和维生素E对主动脉、弹性蛋白部分中钙（Ca）和无机磷（P）水平的比较作用。维生素K2（100毫克/千克体重）和维生素E（40毫克/千克体重）均抑制了动脉粥样硬化大鼠主动脉和弹性蛋白部分中Ca和P的增加。维生素K2（50毫克/千克体重）也抑制了主动脉中Ca和P的沉积，但给予维生素K3或香叶基香叶醇（维生素K2的侧链）后无变化。在体外实验中，维生素K2和维生素E均表现出脂质自由基清除活性。然而，在上述实验条件下，维生素K3和香叶基香叶醇均未表现出抗动脉粥样硬化或自由基清除活性。提示维生素K2和维生素E通过自由基清除活性促进了抗动脉粥样硬化作用。维生素K2的这些作用需要2-甲基萘醌及其侧链（香叶基香叶醇）的结构。
