Seyama Y, Horiuch M, Hayashi M, Kanke Y
Dept. of Clinical Chemistry, Hoshi College of Pharmacy, Tokyo, Japan.
Int J Vitam Nutr Res. 1996;66(1):36-8.
The effect of vitamin K2 on calcium (Ca) and inorganic phosphorus (P) levels in the aorta and kidney obtained from experimental calcinosis induced by vitamin D2(2.5 x 10(5) I.U./ kg b.w.) of male rats was investigated. A high dose of vitamin K2 (100 mg/kg b.w.) inhibited the increase in the aortic Ca and P or in the renal Ca and P induced by vitamin D2, and a low dose of vitamin K2 (10 mg/kg b.w.) showed the same tendency, but the degree of the efficacy was small. It may be suggested that a high dose of vitamin K2 suppressed experimental calcification of soft tissues induced by vitamin D2. Therefore, a pharmacological dose of vitamin K2 might have a usefulness for the prevention and treatment of arteriosclerosis with calcification.
研究了维生素K2对雄性大鼠经维生素D2（2.5×10⁵国际单位/千克体重）诱导的实验性钙化中主动脉和肾脏钙（Ca）及无机磷（P）水平的影响。高剂量维生素K2（100毫克/千克体重）抑制了维生素D2诱导的主动脉钙和磷或肾脏钙和磷的升高，低剂量维生素K2（10毫克/千克体重）也表现出相同趋势，但效果程度较小。可以认为高剂量维生素K2抑制了维生素D2诱导的软组织实验性钙化。因此，药理学剂量的维生素K2可能对预防和治疗伴有钙化的动脉硬化有用。
