Gamisans F, Lacoulonche F, Chauvet A, Espina M, García M L, Egea M A
Physicochemical Unit, Department of Pharmacy, Faculty of Pharmacy, Avda Juan XXIII s/n, 08028, Barcelona, Spain.
Int J Pharm. 1999 Mar 1;179(1):37-48. doi: 10.1016/s0378-5173(98)00381-0.
We report the preparation and evaluation of flurbiprofen loaded-poly-epsilon-caprolactone nanospheres obtained by solvent displacement method. Characterization by thermal methods, infrared spectroscopy and X-ray diffraction analysis can reveal the dispersion state of the drug inside the nanospheres. Such information predicts the stability of the particles and the drug release behaviour. The study has indicated the presence of a molecular dispersed system. In addition, construction of a phase diagram has allowed us to determine the drug/polymer ratios at which flurbiprofen has the highest entrapment efficiency.
我们报告了通过溶剂置换法制备的载有氟比洛芬的聚ε-己内酯纳米球及其评估。通过热方法、红外光谱和X射线衍射分析进行表征，可以揭示药物在纳米球内的分散状态。此类信息可预测颗粒的稳定性和药物释放行为。该研究表明存在分子分散体系。此外，相图的构建使我们能够确定氟比洛芬具有最高包封率时的药物/聚合物比例。
