McAuley J, Shahmanesh M, Swash M
Department of Neurology, The Royal London Hospital, Whitechapel, London E1 1BB, United Kingdom.
Eur J Neurol. 1999 Mar;6(2):235-7. doi: 10.1111/j.1468-1331.1999.tb00018.x.
We describe a patient with an acute illness, with clinical features characteristic of encephalitis lethargica, who responded repeatedly to trials of an apomorphine infusion and subsequently to oral levodopa therapy. This observation implies a direct acute neurotropic effect of the encephalitis on nigral dopaminergic cells. Dopaminergic medication may therefore be helpful in the acute stage of encephalitis lethargica as well as in the delayed post-encephalitic parkinsonian phase of the syndrome.
我们描述了一名患有急性疾病的患者，其临床特征具有昏睡性脑炎的特点，该患者对阿扑吗啡输注试验多次有反应，随后对口服左旋多巴治疗也有反应。这一观察结果表明，脑炎对黑质多巴胺能细胞有直接的急性嗜神经作用。因此，多巴胺能药物可能有助于昏睡性脑炎的急性期以及该综合征的脑炎后帕金森病延迟期。
