细胞溶解型T淋巴细胞反应的遗传控制。II. 宿主基因型在亲代导致F1辐射嵌合体中对三硝基苯修饰的同基因细胞的细胞溶解型T淋巴细胞反应特异性控制中的作用。
Genetic control of cytolytic t-lymphocyte responses. II. The role of the host genotype in parental leads to F1 radiation chimeras in the control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.
作者信息
Billings P, Burakoff S J, Dorf M E, Benacerraf B
出版信息
J Exp Med. 1978 Aug 1;148(2):352-9. doi: 10.1084/jem.148.2.352.
Abstract
Bone marrow cells from C3H (H-2k) mice, a strain that does not exhibit cross-reactive lysis of trinitrophenyl (TNP)-modified allogeneic targets, were allowed to mature in heavily irradiated (B6 times C3H)F1 (H-2b/k) recipients, an F1 hybrid that does demonstrate cross-reactive lysis. Spleen cells from these chimeric mice were removed after 3-4 mo and by H-2 typing shown to be of C3H origin. These cells were found to be tolerant to B6 alloantigens by mixed lymphocyte reaction and cell-mediated cytotoxicity and, when stimulated in vitro with TNP-modified syngeneic cells, now cross-reactively lysed TNP-modified allogeneic targets. These studies demonstrate that the host environment where T cells differentiate influences the specificity of the primary cytolytic T-lymphocyte (CTL) response to TNP-modified syngeneic antigens.
摘要
来自C3H（H-2k）小鼠的骨髓细胞，该品系不会对三硝基苯基（TNP）修饰的同种异体靶标表现出交叉反应性裂解，将其置于经重度照射的（B6×C3H）F1（H-2b/k）受体小鼠体内使其成熟，（B6×C3H）F1是一种确实会表现出交叉反应性裂解的F1杂种小鼠。3至4个月后，从这些嵌合小鼠体内取出脾细胞，通过H-2分型显示其来源于C3H。通过混合淋巴细胞反应和细胞介导的细胞毒性发现，这些细胞对B6同种异体抗原具有耐受性，并且当在体外被TNP修饰的同基因细胞刺激时，现在能够交叉反应性地裂解TNP修饰的同种异体靶标。这些研究表明，T细胞分化所处的宿主环境会影响初始细胞毒性T淋巴细胞（CTL）对TNP修饰的同基因抗原的反应特异性。
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Genetic control of cytolytic t-lymphocyte responses. II. The role of the host genotype in parental leads to F1 radiation chimeras in the control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.细胞溶解型T淋巴细胞反应的遗传控制。II. 宿主基因型在亲代导致F1辐射嵌合体中对三硝基苯修饰的同基因细胞的细胞溶解型T淋巴细胞反应特异性控制中的作用。
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The somatic generation of immune recognition.免疫识别的体细胞产生
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Cross-reactions of HL-A antibodies. V. Relationship between the human HL-A11 and chimpanzee ChW-11 specificities.HL-A抗体的交叉反应。V. 人类HL-A11与黑猩猩ChW-11特异性之间的关系。
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Multiple H-2 linked immune response gene control of H-2 D-associated T-cell-mediated lympholysis to trinitrophenyl-modified autologous cells: Ir-like genes mapping to the left of I-A and within the I region.H-2 D相关的T细胞介导的对三硝基苯基修饰的自体细胞的淋巴细胞溶解的多个H-2连锁免疫反应基因控制：定位于I-A左侧和I区内的类Ir基因。
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The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help.触发病毒加自身特异性细胞毒性T细胞中的淋巴网状系统：T辅助的证据。
J Exp Med. 1978 Mar 1;147(3):897-911. doi: 10.1084/jem.147.3.897.
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On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?关于胸腺在T细胞“组织相容性-2自身识别”分化中的作用：双重识别的证据？
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In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells.在辐射嵌合体中，宿主H-2抗原决定供体细胞毒性细胞的免疫反应性。
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H-2 gene complementation in cytotoxic T cell responses of female against male cells.雌性对雄性细胞的细胞毒性T细胞反应中的H-2基因互补作用。
Eur J Immunol. 1977 Jul;7(7):443-7. doi: 10.1002/eji.1830070708.
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Cytotoxic t-cell response to histocompatibility antigens: the role of H-2.细胞毒性T细胞对组织相容性抗原的反应：H-2的作用。
Cold Spring Harb Symp Quant Biol. 1977;41 Pt 2:519-27. doi: 10.1101/sqb.1977.041.01.060.
9
Cytolytic thymus-derived lymphocytes specific for allogeneic stimulator cells crossreact with chemically modified syngeneic cells.对同种异体刺激细胞具有特异性的溶细胞性胸腺来源淋巴细胞与化学修饰的同基因细胞发生交叉反应。
Proc Natl Acad Sci U S A. 1977 Mar;74(3):1229-33. doi: 10.1073/pnas.74.3.1229.
10
Association of immunity and tolerance to host H-2 determinants in irradiated F1 hybrid mice reconstituted with bone marrow cells from one parental strain.用一个亲本品系的骨髓细胞重建的受照射F1杂种小鼠中对宿主H-2决定簇的免疫与耐受的关联
J Exp Med. 1975 Aug 1;142(2):321-31. doi: 10.1084/jem.142.2.321.
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