细胞毒性T淋巴细胞反应的遗传控制。I. 免疫反应基因对细胞毒性T淋巴细胞针对三硝基苯基修饰的同基因细胞反应特异性的控制。
Genetic control of cytolytic T-lymphocyte responses. I. Ir gene control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.
作者信息
Billings P, Burakoff S J, Dorf M E, Benacerraf B
出版信息
J Exp Med. 1978 Aug 1;148(2):341-50. doi: 10.1084/jem.148.2.341.
Abstract
The ability of cytotoxic T lymphocytes (CTL) induced in vitro to trinitrophenyl (TNP)-modified syngeneic cells to cross-reactively lyse a TNP allogeneic spleen target varies among inbred mouse strains. The cross-reactive CTL phenotype was found to be histocompatibility 2 (H-2) linked and to be dominant in F1 hybrid mice. All strains investigated demonstrated cross-reactivity except for some strains bearing portions of the H-2k haplotype. The gene(s) controlling this response maps to the K and/or I-A region of the H-2 complex. We have termed the immune response (Ir) gene responsible for controlling the specificity of CTL induced to TNP-modified syngeneic cells Ir-X-TNP.
摘要
体外诱导产生的细胞毒性T淋巴细胞（CTL）对三硝基苯基（TNP）修饰的同基因细胞进行交叉反应性裂解同种异体脾靶细胞的能力，在近交系小鼠品系中有所不同。发现交叉反应性CTL表型与组织相容性2（H-2）相关，并且在F1杂种小鼠中占主导地位。除了一些携带H-2k单倍型部分的品系外，所有研究的品系都表现出交叉反应性。控制这种反应的基因定位于H-2复合体的K和/或I-A区域。我们将负责控制对TNP修饰的同基因细胞诱导产生的CTL特异性的免疫反应（Ir）基因称为Ir-X-TNP。
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Genetic control of cytolytic T-lymphocyte responses. I. Ir gene control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.细胞毒性T淋巴细胞反应的遗传控制。I. 免疫反应基因对细胞毒性T淋巴细胞针对三硝基苯基修饰的同基因细胞反应特异性的控制。
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本文引用的文献
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Cell-mediated cytotoxicity to trinitrophenyl-modified syngeneic lymphocytes.对三硝基苯基修饰的同基因淋巴细胞的细胞介导细胞毒性。
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Cell-mediated cytotoxicity, allograft rejection, and tumor immunity.细胞介导的细胞毒性、同种异体移植排斥反应和肿瘤免疫。
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Multiple H-2 linked immune response gene control of H-2 D-associated T-cell-mediated lympholysis to trinitrophenyl-modified autologous cells: Ir-like genes mapping to the left of I-A and within the I region.H-2 D相关的T细胞介导的对三硝基苯基修饰的自体细胞的淋巴细胞溶解的多个H-2连锁免疫反应基因控制：定位于I-A左侧和I区内的类Ir基因。
J Exp Med. 1976 Dec 1;144(6):1701-6. doi: 10.1084/jem.144.6.1701.
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Cross-reactive lysis of trinitrophenyl (TNP)-derivatized H-2 incompatible target cells by cytolytic T lymphocytes generated against syngeneic TNP spleen cells.针对同基因三硝基苯（TNP）脾细胞产生的细胞毒性T淋巴细胞对三硝基苯衍生化的H-2不相容靶细胞的交叉反应性裂解。
J Exp Med. 1976 Dec 1;144(6):1609-20. doi: 10.1084/jem.144.6.1609.
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An estimation of the frequency of precursor cells which generate cytotoxic lymphocytes.对产生细胞毒性淋巴细胞的前体细胞频率的估计。
J Exp Med. 1976 Jun 1;143(6):1562-7. doi: 10.1084/jem.143.6.1562.
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Participation of the H-2 antigens of tumor cells in their lysis by syngeneic T cells.肿瘤细胞的H-2抗原在同基因T细胞介导的细胞裂解中的作用。
J Exp Med. 1976 Mar 1;143(3):601-14. doi: 10.1084/jem.143.3.601.
7
Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex.针对H-2复合体K和D位点产物的同种抗血清对三硝基苯基衍生化靶细胞的细胞介导细胞溶解作用的抑制。
Proc Natl Acad Sci U S A. 1976 Feb;73(2):625-9. doi: 10.1073/pnas.73.2.625.
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Interaction antigens detected by cytotoxic T cells with the major histocompatibility complex as modifier.细胞毒性T细胞检测到的相互作用抗原，以主要组织相容性复合体作为修饰因子。
Nature. 1975 Jul 31;256(5516):419-21. doi: 10.1038/256419a0.
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Inhibition of T-lymphocyte-mediated tumor-specific lysis by alloantisera directed against the H-2 serological specificities of the tumor.针对肿瘤H-2血清学特异性的同种抗血清对T淋巴细胞介导的肿瘤特异性溶解的抑制作用。
J Exp Med. 1975 Oct 1;142(4):1023-8. doi: 10.1084/jem.142.4.1023.
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Quantitative studies of the activation of cytotoxic lymphocyte precursor cells.细胞毒性淋巴细胞前体细胞激活的定量研究。
Immunol Rev. 1977;35:38-58. doi: 10.1111/j.1600-065x.1977.tb00234.x.
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