阿司匹林和吲哚美辛对Walker瘤大鼠溶骨性肿瘤沉积物及高钙血症的抑制作用及其在人类乳腺癌中的可能应用。
The inhibition by aspirin and indomethacin of osteolytic tumor deposits and hypercalcaemia in rats with Walker tumour, and its possible application to human breast cancer.
作者信息
Powles T J, Clark S A, Easty D M, Easty G C, Neville A M
出版信息
Br J Cancer. 1973 Oct;28(4):316-21. doi: 10.1038/bjc.1973.154.
Abstract
Walker carcinosarcoma cells cause in vitro osteolysis which may be inhibited by aspirin. In the rat, this tumour produces osteolytic bone deposits and hypercalcaemia, both of which can be prevented by aspirin and indomethacin, whereas soft tissue tumour deposits are unaffected by these drugs. Some human breast tumours cause in vitro osteolysis which may be inhibited by aspirin.
摘要
沃克癌肉瘤细胞会导致体外骨溶解，而阿司匹林可能会抑制这种情况。在大鼠中，这种肿瘤会产生溶骨性骨沉积物和高钙血症，这两种情况都可以通过阿司匹林和吲哚美辛预防，而软组织肿瘤沉积物则不受这些药物影响。一些人类乳腺肿瘤会导致体外骨溶解，阿司匹林可能会抑制这种情况。
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