Bertazzoli C, Sala L, Ballerini L, Watanabe T, Folkers K
Res Commun Chem Pathol Pharmacol. 1976 Dec;15(4):797-800.
Rabbits were injected with adriamycin 3 days/week/7 weeks. Heart tissues of treated rabbits showed myocardial degeneration, but the tissues of controls were normal. The deficiency in the activity of the succinate dehydrogenase-coenzyme Q10 reductase in the heart tissues of the rabbits treated with adriamycin was higher (0.001 less than P less than 0.01) than that for control tissues. These data indicate a correlation of at least a part of the cardiotoxicity of adriamycin in cancer patients to inhibition of CoQ10-enzymes, since coenzyme Q10 is indispensable to bioenergetics in the myocardium of both humans and rabbit.
每周3天，连续7周给兔子注射阿霉素。接受治疗的兔子的心脏组织出现心肌变性，但对照组的组织正常。阿霉素治疗的兔子心脏组织中琥珀酸脱氢酶 - 辅酶Q10还原酶的活性缺乏比对照组织更高（0.001 < P < 0.01）。这些数据表明，阿霉素对癌症患者的心脏毒性至少有一部分与辅酶Q10酶的抑制有关，因为辅酶Q10对人和兔子心肌的生物能量学都是必不可少的。
