Choe J Y, Combs A B, Saji S, Folkers K
Res Commun Chem Pathol Pharmacol. 1979 Jun;24(3):595-8.
Administration of an acutely toxic dose of doxorubicin to mice did not increase, but rather decreased the percent deficiency of coenzyme Q10 (CoQ10) as calculated according to the coenzyme-apoenzyme system principle. The date indicate that doxorubicin may occupy CoQ10-empty receptors on the apoenzyme, with or without some destruction of enzyme-menbrane structure close to the receptor. Data from mice receiving both CoQ10 and doxorubicin indicated that CoQ10 may protect against doxorubicin. CoQ10 alone corrected the pre-existing deficiency found in control mice.
给小鼠急性给予毒性剂量的阿霉素后，根据辅酶-脱辅基酶系统原理计算，辅酶Q10（CoQ10）的缺乏百分比并未增加，反而降低。数据表明，阿霉素可能占据脱辅基酶上CoQ10空缺的受体，无论受体附近的酶膜结构是否有一定破坏。接受CoQ10和阿霉素的小鼠的数据表明，CoQ10可能对阿霉素有保护作用。单独使用CoQ10可纠正对照小鼠中预先存在的缺乏情况。
