Shetty N, Srinivasan S, Holton J, Ridgway G L
Department of Clinical Microbiology, University College London Hospitals.
J Hosp Infect. 1999 Feb;41(2):101-5. doi: 10.1016/s0195-6701(99)90046-4.
The microbicidal activity of a new disinfectant Sterilox, a super-oxidized water, containing a mixture of oxidizing substances, was tested against Clostridium difficile spores, Helicobacter pylori, vancomycin resistant Enterococcus species, Candida albicans and several Mycobacterium species using membrane filters. All tests were performed in duplicate with and without added horse serum at 1% and 5% v/v. Distilled water, 0.35% peracetic acid (Nu-Cidex) and 2% glutaraldehyde were included as controls. Sterilox: spore suspension (9:1 v/v) achieved log10 kill of > 5 with 5% horse serum in 2 min against H. pylori, vancomycin resistant Enterococcus species, C. albicans and four atypical Mycobacterium species: M. avium, M. chelonei, M. xenopi and M. smegmatis. Sporicidal activity of Sterilox against Clostridium difficile was markedly diminished in the presence of 5% horse serum. Sterilox may be an effective alternative in endoscopy units, as it is a potent microbicidal agent and the manufacturer claims it is not corrosive to metal and is nontoxic to biological tissues.
一种新型消毒剂Sterilox（一种超氧化水，含有多种氧化物质的混合物），使用膜滤器对艰难梭菌孢子、幽门螺杆菌、耐万古霉素肠球菌、白色念珠菌和几种分枝杆菌进行了杀菌活性测试。所有测试均一式两份，分别在添加和不添加1%和5%（v/v）马血清的情况下进行。蒸馏水、0.35%过氧乙酸（Nu-Cidex）和2%戊二醛作为对照。Sterilox：在含有5%马血清的情况下，孢子悬液（9:1，v/v）在2分钟内对幽门螺杆菌、耐万古霉素肠球菌、白色念珠菌和四种非典型分枝杆菌（鸟分枝杆菌、龟分枝杆菌、偶发分枝杆菌和耻垢分枝杆菌）实现了log10>5 的杀灭率。在5%马血清存在的情况下，Sterilox对艰难梭菌的杀孢子活性明显降低。Sterilox可能是内镜科室的一种有效替代品，因为它是一种强效杀菌剂，并且制造商声称它对金属无腐蚀性，对生物组织无毒。
