Middleton A M, Chadwick M V, Sanderson J L, Gaya H
Department of Microbiology, Royal Brompton Hospital, London, UK.
J Hosp Infect. 2000 Aug;45(4):278-82. doi: 10.1053/jhin.2000.0772.
The efficacy of Sterilox, a super-oxidized water holding a reduction/oxidation potential of greater than 950 mV was compared with the efficacy of glutaraldehyde against clinical isolates of Mycobacterium tuberculosis and Mycobacterium avium-intracellulare. An in use method using an automated bronchoscope washing machine demonstrated that over five cycles, Sterilox with a contact time of 5 min gave log10 reduction factors for M. tuberculosis and M. avium-intracellulare of >6 and >5, respectively. Glutaraldehyde with a contact time of 10 min gave log10 reduction factors for both M. tuberculosis and M. avium-intracellulare of >4, and at a contact time of 20 min >5 each. The non-toxic nature of Sterilox, together with the reduction in viable counts demonstrated in this study, suggest that the solution is an effective alternative mycobactericidal agent to the established disinfectants for the disinfection of bronchoscopes and, therefore, justifies further investigation.
将氧化还原电位大于950 mV的超氧化水Sterilox与戊二醛对结核分枝杆菌和鸟分枝杆菌复合群临床分离株的杀菌效果进行了比较。使用自动支气管镜清洗机的实际使用方法表明，在五个循环中，接触时间为5分钟的Sterilox对结核分枝杆菌和鸟分枝杆菌复合群的对数减少因子分别>6和>5。接触时间为10分钟的戊二醛对结核分枝杆菌和鸟分枝杆菌复合群的对数减少因子均>4，接触时间为20分钟时，每种菌的对数减少因子均>5。Sterilox的无毒性质以及本研究中显示的活菌数减少表明，该溶液是用于支气管镜消毒的既定消毒剂的一种有效的替代杀分枝杆菌剂，因此有理由进行进一步研究。
