Strome S E, To W, Strawderman M, Gersten K, Devaney K O, Bradford C R, Esclamado R M
Department of Otolaryngology, Mayo Clinic, Rochester, USA.
Otolaryngol Head Neck Surg. 1999 Mar;120(3):375-9. doi: 10.1016/S0194-5998(99)70278-0.
The purpose of this study was to establish treatment criteria for patients with early-stage squamous cell carcinoma of the buccal mucosa. Thirty-one patients were analyzed in a retrospective fashion. Distribution of patients according to tumor stage was relatively even. Within 5 years recurrent disease developed in nearly 80% of evaluable patients. There was a 100% overall incidence of local disease recurrence for patients with stage I and II tumors treated with wide local excision alone and followed up for more than 2 years. On the basis of these data, we conclude that wide local excision for early-stage buccal carcinoma is associated with a high local failure rate. Possible causes for failure and alternative treatment approaches are discussed.
本研究的目的是建立颊黏膜早期鳞状细胞癌患者的治疗标准。对31例患者进行了回顾性分析。根据肿瘤分期的患者分布相对均匀。在5年内，近80%的可评估患者出现了复发性疾病。仅接受广泛局部切除并随访超过2年的I期和II期肿瘤患者，局部疾病复发的总发生率为100%。基于这些数据，我们得出结论，早期颊癌的广泛局部切除与高局部失败率相关。讨论了失败的可能原因和替代治疗方法。
