Naqui S Z, Harris B S, Thomaidou D, Parnavelas J G
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
Brain Res Dev Brain Res. 1999 Mar 12;113(1-2):75-82. doi: 10.1016/s0165-3806(99)00003-6.
Cajal-Retzius cells are neurons prominently located in layer I of the developing cerebral cortex. They are the first neurons to be born in the cortex reaching maturity long before any other cortical neuronal cell type; later in development they degenerate and/or change phenotype. The noradrenergic system, which originates in the locus coeruleus in the brain stem, is one of the earliest axonal systems to enter the cortex forming contacts with Cajal-Retzius cells in layer I. Here we followed the course of development of the Cajal-Retzius cells in postnatal life in animals depleted of noradrenaline in the cortex. We found that removal of this system after birth resulted in significantly more Cajal-Retzius cells during the first 2 weeks of life. This may be due to the observed decline in the number of dying cells in layer I of these animals during the same period. We speculate that the noradrenergic system regulates the development of Cajal-Retzius cells which have been implicated in neuronal migration and laminar formation in the cerebral cortex.
卡哈尔-雷特齐乌斯细胞是主要位于发育中的大脑皮质第I层的神经元。它们是皮质中最早生成的神经元，早在任何其他皮质神经元细胞类型成熟之前就已成熟；在发育后期，它们会退化和/或改变表型。去甲肾上腺素能系统起源于脑干的蓝斑，是最早进入皮质并与第I层的卡哈尔-雷特齐乌斯细胞形成联系的轴突系统之一。在此，我们追踪了皮质中去甲肾上腺素缺乏的动物出生后卡哈尔-雷特齐乌斯细胞的发育过程。我们发现，出生后去除该系统会导致在出生后的前2周内卡哈尔-雷特齐乌斯细胞显著增多。这可能是由于在此期间观察到这些动物第I层中死亡细胞数量减少所致。我们推测，去甲肾上腺素能系统调节卡哈尔-雷特齐乌斯细胞的发育，而这些细胞与大脑皮质中的神经元迁移和层状形成有关。
