Kharazmi A, Kemp K, Ismail A, Gasim S, Gaafar A, Kurtzhals J A, El Hassan A M, Theander T G, Kemp M
Center for Medical Parasitology, Department of Clinical Microbiology, University Hospital, Copenhagen, Denmark.
Immunol Lett. 1999 Jan;65(1-2):105-8. doi: 10.1016/s0165-2478(98)00132-1.
In the present communication we provide evidence for the existence of a Th1/Th2 dichotomy in the T-cell response to Leishmania antigens in human leishmaniasis. Our data suggest that the pattern of IL-4 and IFN-gamma response is polarised in these patients. Lymphocytes from individuals recovered from cutaneous leishmaniasis (CL) responded by IFN-gamma production following stimulation with Leishmania antigens whereas cells from patients recovered from visceral leishmaniasis (VL) showed a mixed pattern of IFN-gamma and IL-4 responses. The cells producing these cytokines were predominantly CD4+. Furthermore, IL-10 plays an important role in the development of post kala azar dermal leishmaniasis (PKDL) from VL. The balance between the parasitic-specific T-cell response plays an important regulatory role in determining the outcome of Leishmania infections in humans.
在本通讯中，我们提供了证据，证明在人类利什曼病中，T细胞对利什曼原虫抗原的反应存在Th1/Th2二分法。我们的数据表明，这些患者中白细胞介素-4（IL-4）和干扰素-γ（IFN-γ）的反应模式是极化的。来自皮肤利什曼病（CL）康复个体的淋巴细胞在用利什曼原虫抗原刺激后通过产生IFN-γ做出反应，而来自内脏利什曼病（VL）康复患者的细胞则表现出IFN-γ和IL-4反应的混合模式。产生这些细胞因子的细胞主要是CD4+。此外，白细胞介素-10在VL患者的黑热病后皮肤利什曼病（PKDL）的发展中起重要作用。寄生虫特异性T细胞反应之间的平衡在决定人类利什曼原虫感染的结果中起重要的调节作用。
