Goudreau P N, Stock A M
Center for Advanced Biotechnology and Medicine, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, 679 HoesLane, Piscataway, NJ 08854-5638, USA.
Curr Opin Microbiol. 1998 Apr;1(2):160-9. doi: 10.1016/s1369-5274(98)80006-4.
In bacteria, adaptive responses to changing environmental conditions are mediated by signal transduction systems that involve modular protein domains. Despite great diversity in the integration of domains into different systems, studies of individual components have revealed molecular strategies that are widely applicable. Studies of receptors have advanced our understanding of how information is transmitted across membranes, the determination of three-dimensional structures of domains of histidine protein kinase domains and response regulator proteins has begun to reveal the molecular basis of signaling via two-component phosphoryltransfer pathways, and the description of 'eukaryotic-like' protein domains involved in bacterial signaling has emphasized the universality of intracellular signaling mechanisms.
在细菌中，对不断变化的环境条件的适应性反应是由涉及模块化蛋白质结构域的信号转导系统介导的。尽管结构域整合到不同系统中的方式具有很大的多样性，但对单个组件的研究已经揭示了广泛适用的分子策略。对受体的研究增进了我们对信息如何跨膜传递的理解，对组氨酸蛋白激酶结构域和反应调节蛋白结构域三维结构的确定已开始揭示通过双组分磷酸转移途径进行信号传导的分子基础，而对参与细菌信号传导的“类真核”蛋白质结构域的描述则强调了细胞内信号传导机制的普遍性。
