Kobayashi S, Otsu H, Noda Y
Division of Physiology and Pathology, National Institute of Radiological Sciences, Chiba, Japan.
Jikken Dobutsu. 1994 Jul;43(3):351-6. doi: 10.1538/expanim1978.43.3_351.
Athymic (nu/nu) and euthymic (nu/+) mice were intraperitoneally given doses of 0.25 to 1.5 mg/g body weight of urethan at the age of 14 to 16 days. Dose-response relationship and sequential changes in lung tumorigenesis induced by urethan in athymic mice were compared with those in euthymic littermates. The urethan dose-response relationship in lung tumorigenesis of the nu/nu mice was almost the same as that in the nu/+ mice. Incidence and multiplicity of the lung tumors were investigated sequentially 28 days to 12 months after urethan injection. They showed similar indexes in the two phenotypically different mice at varying periods after 0.5 mg/g body weight urethan treatment (incidences of 4.8 and 4.4 tumors/mouse and 96 and 97% for nu/nu and nu/+ mice, respectively, at 12 months after treatment). This means that the length of the latent period is similar in these phenotypically different mice. It may be concluded that the immunosurveillance mechanism mediated by T-cells does not function in the present model.
无胸腺（nu/nu）和有胸腺（nu/+）小鼠在14至16日龄时腹腔注射剂量为0.25至1.5毫克/克体重的乌拉坦。将乌拉坦诱导的无胸腺小鼠肺肿瘤发生的剂量反应关系和序列变化与有胸腺的同窝小鼠进行比较。nu/nu小鼠肺肿瘤发生中的乌拉坦剂量反应关系与nu/+小鼠几乎相同。在注射乌拉坦后28天至12个月依次研究肺肿瘤的发生率和多发性。在0.5毫克/克体重乌拉坦处理后的不同时期，这两种表型不同的小鼠显示出相似的指标（处理后12个月时，nu/nu和nu/+小鼠的肿瘤发生率分别为每只小鼠4.8个和4.4个，肿瘤发生比例分别为96%和97%）。这意味着在这些表型不同的小鼠中潜伏期长度相似。可以得出结论，在当前模型中由T细胞介导的免疫监视机制不起作用。
