Inomata T, Ninomiya H, Kawakami S, Sakaguchi K, Sakita K, Aoyama S, Shirai M, Masaoka T, Akahori F
Department of Laboratory Animal Science, College of Environmental Health, Azabu University, Kanagawa, Japan.
Exp Anim. 1996 Oct;45(4):385-8. doi: 10.1538/expanim.45.385.
Fetal thyroid glands of athymic nude mice (BALB/cAnNCrj-nu/nu) were examined morphometrically on day 18 of gestation. Compared to euthymic litter mate controls (BALB/ cAnNCrj-nu/+), both the cell height and diameter of thyroid follicles were significantly smaller; fewer well-developed follicles were found in the peripheral region of the thyroid; the body weight and total volume of the thyroid gland were also smaller in nude mice. These results suggest underdevelopment of the fetal thyroid gland of the athymic nude mouse.
在妊娠第18天对无胸腺裸鼠（BALB/cAnNCrj-nu/nu）的胎儿甲状腺进行形态计量学检查。与有胸腺的同窝对照小鼠（BALB/cAnNCrj-nu/+）相比，甲状腺滤泡的细胞高度和直径均显著更小；在甲状腺周边区域发现发育良好的滤泡较少；裸鼠的甲状腺体重和总体积也更小。这些结果提示无胸腺裸鼠胎儿甲状腺发育不全。
