West K, Petrie L, Haines D M, Konoby C, Clark E G, Martin K, Ellis J A
Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
Vaccine. 1999 Feb 26;17(7-8):809-20. doi: 10.1016/s0264-410x(98)00265-5.
The effect of vaccination with a formalin-inactivated, alum-precipitated (FI), bovine respiratory syncytial virus (BRSV) vaccine on BRSV induced respiratory disease in calves was investigated. Six month old BRSV-naive calves were vaccinated with either a FI, a modified live virus (MLV), or virus antigen negative control vaccine (n = 4 per group). One month after the second vaccination, the calves were aerosol challenged with lung wash from a newborn calf infected with a field isolate of BRSV. Moderate to severe clinical disease occurred in all calves. Calves that received FI vaccine had a significantly earlier (day 2 vs. day 4-5) onset of pyrexia and dyspnea (P < 0.05). Pulmonary lesions, consisting of cranioventral atelectasis and dorsal emphysema, occurred in all groups. Two calves that received MLV, and three that received FI vaccine, had reduced pneumonic lung area relative to controls. Vaccination with the FI vaccine resulted in more rapid onset of clinical disease, but ultimately, reduced pulmonary pathology in most recipients.
研究了用福尔马林灭活、明矾沉淀（FI）的牛呼吸道合胞病毒（BRSV）疫苗对BRSV诱导的犊牛呼吸道疾病的影响。将6月龄未接触过BRSV的犊牛分为三组，分别接种FI疫苗、改良活病毒（MLV）疫苗或病毒抗原阴性对照疫苗（每组n = 4头）。第二次接种疫苗1个月后，用感染了BRSV田间分离株的新生犊牛的肺灌洗物对犊牛进行气溶胶攻击。所有犊牛均出现中度至重度临床疾病。接受FI疫苗的犊牛发热和呼吸困难的发病时间明显更早（第2天对比第4 - 5天）（P < 0.05）。所有组均出现由颅腹侧肺不张和背侧气肿组成的肺部病变。与对照组相比，接受MLV疫苗的2头犊牛和接受FI疫苗的3头犊牛的肺炎肺面积减小。接种FI疫苗导致临床疾病发病更快，但最终，大多数接种疫苗的犊牛肺部病理学变化减轻。
