Wang X, Wang B, Chen C, Yang J, Fang Z, Zuckerman B, Xu X
Department of Pediatrics, Boston University School of Medicine and Boston Medical Center, MA 02118, USA.
Am J Epidemiol. 1999 Mar 1;149(5):412-20. doi: 10.1093/oxfordjournals.aje.a009828.
This study investigated blood pressure in 1,183 Chinese nuclear families (mother, father, and first two children) via a cross-sectional 1994-1997 survey. The mother's, the father's, and the first sibling's blood pressures were each significantly and independently related to the second sibling's blood pressure after adjustment for sex, age, height, weight, education, smoking, and alcohol consumption. The association was consistent across the four age strata (6-10, 11-14, 15-19, and > or = 20 years). The rate of high systolic blood pressure in the second sibling was lowest (2.3%) when both parents and the first sibling were in the low blood pressure tertile (low-low group) and highest (26.0%) when these family members were in the high blood pressure tertile (high-high group). The rate was intermediate if only the parents (10.7%, high-low group) or the first sibling (8.4%, low-high group) was in the high blood pressure tertile. As compared with the low-low group, the odds ratios for the high-high, high-low, and low-high groups were 14.3 (95% confidence interval 4.3-48.2), 4.3 (95% confidence interval 1.2-15.6), and 3.9 (95% confidence interval 1.1-14.4), respectively. A similar pattern was found for diastolic blood pressure. The data indicate a strong familial aggregation of blood pressure in this population and show that such a familial influence on blood pressure can be detected from early childhood onward.
本研究通过1994 - 1997年的横断面调查，对1183个中国核心家庭（母亲、父亲和头两个孩子）的血压进行了调查。在对性别、年龄、身高、体重、教育程度、吸烟和饮酒情况进行调整后，母亲、父亲和第一个兄弟姐妹的血压均与第二个兄弟姐妹的血压显著且独立相关。这种关联在四个年龄层（6 - 10岁、11 - 14岁、15 - 19岁和≥20岁）中是一致的。当父母和第一个兄弟姐妹都处于低血压三分位数时（低 - 低组），第二个兄弟姐妹的高收缩压发生率最低（2.3%）；当这些家庭成员处于高血压三分位数时（高 - 高组），发生率最高（26.0%）。如果只有父母（10.7%，高 - 低组）或第一个兄弟姐妹（8.4%，低 - 高组）处于高血压三分位数，发生率则处于中间水平。与低 - 低组相比，高 - 高组、高 - 低组和低 - 高组的比值比分别为14.3（95%置信区间4.3 - 48.2）、4.3（95%置信区间1.2 - 15.6）和3.9（95%置信区间1.1 - 14.4）。舒张压也发现了类似的模式。数据表明该人群中血压存在强烈的家族聚集性，并表明这种对血压的家族影响从幼儿期就可以检测到。
