Wilson D K, Klesges L M, Klesges R C, Eck L H, Hackett-Renner C A, Alpert B S, Dalton E T
Department of Pediatrics, University of Tennessee, Memphis.
J Clin Epidemiol. 1992 Sep;45(9):959-69. doi: 10.1016/0895-4356(92)90112-z.
In a prospective study, we evaluated familial aggregation of blood pressure in a sample of 175 normotensive families with children 3 to 6 yr old. Systolic and diastolic blood pressure measurements of parents and children were correlated at 1, 2, and 3 yr intervals. Spearman rank-order correlation coefficients between parents and children were significant for mother-son pairs. In particular, mother-son blood pressure correlation coefficients were significant for systolic blood pressure across all 3 yr and for diastolic blood pressure during yr 2. Further analyses were performed adjusting for body mass index (BMI), age, physical activity, sodium intake, potassium intake, and parental smoking status, and alcohol use. The Spearman correlation coefficients for mother-son pairs remained significant for yr 1 and 3 after adjusting for these blood pressure correlates. These results are consistent with cross-sectional studies and suggest that both genetic and environmental contributions to blood pressure status are important in young children.
在一项前瞻性研究中，我们评估了175个有3至6岁子女的血压正常家庭样本中的血压家族聚集性。父母和子女的收缩压和舒张压测量值每隔1、2和3年进行一次相关性分析。父母与子女之间的斯皮尔曼等级相关系数在母子对中具有显著性。特别是，母子血压相关系数在所有3年中的收缩压以及第2年中的舒张压方面均具有显著性。我们还进行了进一步分析，对体重指数（BMI）、年龄、身体活动、钠摄入量、钾摄入量以及父母吸烟状况和饮酒情况进行了校正。校正这些血压相关因素后，母子对的斯皮尔曼相关系数在第1年和第3年仍然具有显著性。这些结果与横断面研究一致，表明遗传和环境因素对幼儿血压状况都很重要。
