Ziada A M, Al Kharusi W, Hassan M O
Department of Physiology, College of Medicine, Sultan Qaboos University, P O Box 35, Al Khod-123, Muscat, Sultanate of Oman.
J Sci Res Med Sci. 2001 Oct;3(2):81-5.
To study blood pressure and blood pressure reactivity in young offspring of normotensive or hypertensive parents who are consanguineous (first cousins) or are not blood-related.
Blood pressure, heart rate and body mass index (BMI) were measured in 9-10 year-old male offspring of 19 pairs of first-cousins normotensive, 16 pairs of first-cousin hypertensive and 12 pairs of non-blood-related hypertensive parents.
The offspring of first-cousin hypertensive parents exhibited the greatest systolic and diastolic blood pressure reactivity to their first casual blood pressure measurement, while the offspring of first-cousin normotensive parents showed the least reactivity. The offspring of the hypertensive parents who were not blood-related showed an intermediate reactivity. Basal systolic blood pressure (SBP) was also highest in the offspring of first-cousin hypertensive parents, and their basal diastolic blood pressure (DBP) was higher than that in offspring of first-cousin normotensive parents.
The augmented blood pressure response in the offspring of hypertensive parents may have prognostic implications and serve as an important and significant indicator of predisposition to hypertension later in life.
研究血压正常或高血压的近亲（一级表亲）或非血亲父母的年轻后代的血压及血压反应性。
对19对血压正常的一级表亲、16对高血压一级表亲以及12对非血亲高血压父母的9至10岁男性后代测量血压、心率和体重指数（BMI）。
高血压一级表亲父母的后代对首次偶然血压测量表现出最大的收缩压和舒张压反应性，而血压正常的一级表亲父母的后代反应性最小。非血亲高血压父母的后代反应性处于中间水平。高血压一级表亲父母的后代基础收缩压（SBP）也最高，其基础舒张压（DBP）高于血压正常的一级表亲父母的后代。
高血压父母后代中增强的血压反应可能具有预后意义，并且是日后发生高血压易感性的一个重要且显著的指标。
