Hu Yang, He Liu, Wu Yangfeng, Ma Guansheng, Li Liming, Hu Yonghua
Department of Epidemiology and Biostatistics, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China.
BMC Public Health. 2013 Jul 26;13:686. doi: 10.1186/1471-2458-13-686.
It remains unclear whether the body mass index (BMI) and blood pressure (BP) profile are clustered within families in Chinese Han population. The aim of this study is to explore familial aggregation and parent-offspring correlations of BMI and blood pressure in Chinese Han population.
6,369 Han nucleus families, consisting of parents and at least one biological adult child who were living together, were enrolled from the nation-wide cross-sectional study (China National Nutrition and Health Survey) which was conducted in 2002, with a total number of 19,107 participants aged 18-64 years (6,369 sets of parents, 4,132 sons and 2,237 daughters). Family aggregation (Intra-class correlations, ICCs) and parent-offspring correlations in BMI, systolic BP (SBP) and diastolic BP (DBP) were estimated using linear mixed effect regression models.
BMI and BP levels in two generations and ICCs of BMI, SBP and DBP varied across the country. Familial aggregation of overweight/obesity was observed in rural area (ICC=5.4%, p<0.05), and high BP (defined as SBP ≥ 120 mmHg or DBP ≥ 80 mmHg) was more common in low income families (ICC=4.4%, p<0.05) compared to middle income (ICC=1.9%) and high income families (ICC=2.6%). Additionally, offspring with more parents being overweight/obese tend to have higher BMI. The similar trend was found for high BP. However, we did not observe that same-sex parent-offspring correlations of BMI and BP were stronger than the correlations for mother-son or father-daughter.
Our study suggested that familial environments, alongside the impact of genetic factors, could be important non-communicable chronic diseases (NCD) risk factors. Family-based intervention taking both mother and father into account might have great potential in NCD prevention for younger generation.
在中国汉族人群中，体重指数（BMI）和血压（BP）分布是否在家庭内部聚集尚不清楚。本研究旨在探讨中国汉族人群中BMI和血压的家族聚集性及亲子相关性。
从2002年开展的全国性横断面研究（中国居民营养与健康状况调查）中纳入6369个汉族核心家庭，这些家庭由父母和至少一名共同生活的亲生成年子女组成，共有19107名年龄在18 - 64岁的参与者（6369对父母、4132名儿子和2237名女儿）。使用线性混合效应回归模型估计BMI、收缩压（SBP）和舒张压（DBP）的家族聚集性（组内相关系数，ICCs）及亲子相关性。
两代人的BMI和血压水平以及BMI、SBP和DBP的ICCs在全国范围内存在差异。农村地区观察到超重/肥胖的家族聚集性（ICC = 5.4%，p < 0.05），与中等收入家庭（ICC = 1.9%）和高收入家庭（ICC = 2.6%）相比，低收入家庭中高血压（定义为SBP≥120 mmHg或DBP≥80 mmHg）更为常见（ICC = 4.4%，p < 0.05）。此外，父母超重/肥胖的子女往往BMI更高。高血压也发现了类似趋势。然而，我们没有观察到BMI和血压的同性亲子相关性比母子或父女相关性更强。
我们的研究表明，除遗传因素的影响外，家庭环境可能是重要的非传染性慢性病（NCD）风险因素。考虑到父母双方的家庭干预在预防年轻一代的NCD方面可能具有巨大潜力。
