用67Ga螯合物标记血小板。

Platelet labeling with 67Ga chelates.

作者信息

Karanikas G, Rodrigues M, Granegger S, Sinzinger H

机构信息

Department of Nuclear Medicine, University of Vienna, Austria.

出版信息

Appl Radiat Isot. 1999 Mar;50(3):505-11. doi: 10.1016/s0969-8043(98)00084-0.

DOI:10.1016/s0969-8043(98)00084-0

PMID:10070710

Abstract

68Ga-labeled platelets could be useful for positron emission tomographic (PET) studies. In order to identify the optimal chelate for radiolabeling of platelets with 68Ga, we investigated the platelet uptake of 67Ga-oxine, -tropolone and -MPO. The platelet uptake of 67Ga-oxine and -tropolone is very low (< 5%). The platelet uptake of 67Ga-MPO, in contrast, increases with platelet density (highest at 10(9) platelets/ml) up to 18%. Our data provide evidence that only 68Ga-MPO could be useful for PET-studies.

摘要

68Ga标记的血小板可用于正电子发射断层扫描（PET）研究。为了确定用68Ga对血小板进行放射性标记的最佳螯合剂，我们研究了67Ga-喔星、-托酚酮和-MPO在血小板中的摄取情况。67Ga-喔星和-托酚酮在血小板中的摄取非常低（<5%）。相比之下，67Ga-MPO在血小板中的摄取随血小板密度增加（在10⁹个血小板/毫升时最高），可达18%。我们的数据表明只有68Ga-MPO可用于PET研究。